DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35D1 and Ugt2a3

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_082370.2	Gene:	Ugt2a3 / 72094	MGIID:	1919344	Length:	534	Species:	Mus musculus

Alignment Length:	549	Identity:	169/549 - (30%)
Similarity:	280/549 - (51%)	Gaps:	65/549 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FLLVCLLPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYP-------QREP-- 60
            |||.....|....:::| |:|. ..||:......|:.|.:.|||:| |..||       :|.|
Mouse    11 FLLQLCWAGCGFCSKVL-VWPC-DMSHWLNLKTILEELGARGHEVT-VLKYPSIIIDQSKRIPLH 72

  Fly    61 FRNIHDIPVPEVFEN-FNEVLRIAST--PR-STWQSSDFINEYVLNLTKTVLNNEGVRRDILGPQ 121
            |.||..:...|..|| .||:..:|..  |. |.|:::..:.::.|.:|.   :.|.:.|.:|..|
Mouse    73 FENIPLLYEIETAENRLNEIANLAVNVIPNLSLWEAAKTLQDFFLQVTG---DFESICRSVLYNQ 134

  Fly   122 K-------PHFDLVIMDLWRMDVLSG--LAAYFDAPIIGMASYGTDWKIDELMGNVS-PISYLQS 176
            |       ..:|:|::|   ..|..|  :|.....|.:....:...:.:::..|.:. |:||:..
Mouse   135 KFMDKLRDAQYDVVVID---PVVPCGELVAEVLQIPFVYTLRFSMGYYMEKHCGQLPIPLSYVPV 196

  Fly   177 PSSRFYDLEAYGERLLHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAER-----KPLSEISRNF 236
            ..|...|...:.||:.::|   ||.:...|.. :.....:.||:.....|     |.:.:.
Mouse   197 VMSELTDNMTFTERVKNMM---FSLLFEYWLQ-QYDFAFWDQFYSETLGRPTTFCKTVGKA---- 253

  Fly   237 DLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKS 301
            |:.|:..::.:..||||:||...|||||. ...:.|..|::.|:|.:||.||:.||||:.|  |:
Mouse   254 DIWLIRTYWDVEFPRPYLPNFEFVGGLHC-KPAKPLPKEMEEFVQSSGEHGVVVFSLGSMV--KN 315

  Fly   302 LSEDRRKVLLETFASLPQRIVWKFEDELLPGKPP-----NVFISKWFPQQAILAHPNVKLFITHG 361
            |:|::..::....|.:||:::|::.     ||.|     |..:..|.||..:|.||..|.|||||
Mouse   316 LTEEKANLIASVLAQIPQKVLWRYS-----GKKPATLGSNTRLFNWIPQNDLLGHPKTKAFITHG 375

  Fly   362 GLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEE 426
            |.....|:|:||.||:|:|.|.||..|:.|:...|..|.::|..|||.:..|.:..::...|::|
Mouse   376 GTNGIYEAIYHGVPMVGVPMLGDQPHNIAHMEAKGAALKVSISTMTSTDLLSAVRAVINEPSYKE 440

  Fly   427 TARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALVIL 491
            .|...:..:.|||:||::.|::|.|:|:.||||.|::||..||.:.:||||||.|      .::|
Mouse   441 NAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIG------FLLL 499

  Fly   492 GIVTYLLVMTLRKCLFLIKRGKCEAIKKI 520
            .:||...::| :.|||:.::...:..||:
Mouse   500 CVVTLTFIIT-KFCLFVCQKLYMKESKKM 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	148/489 (30%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	160/513 (31%)
Ugt2a3	NP_082370.2	UDPGT	25..526	CDD:278624	163/532 (31%)
Ugt2a3	NP_082370.2	egt	<268..507	CDD:223071	98/252 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840279
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55988
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	1	0.950	-	0	Normalized mean entropy	S5897
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.640