DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and Ugt2b1

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_690024.1	Gene:	Ugt2b1 / 71773	MGIID:	1919023	Length:	529	Species:	Mus musculus

Alignment Length:	549	Identity:	158/549 - (28%)
Similarity:	266/549 - (48%)	Gaps:	86/549 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IFLLVCLLPGYSEGA--RILAVFPLPSSSHYFFALPYLKSLASLGHEIT------SVSPYPQREP 60
            :|||:..:.....||  ::| |:| ...||:......|..|...||::|      |:...|..|.
Mouse     8 VFLLIQFICYIRPGACGKVL-VWP-TEYSHWINMKIILDELVQRGHDVTVLISSASILIGPSNES 70

  Fly    61 FRN--IHDIPVPE-----VFENF--NEVLRIASTPRSTWQS-----------SDFINEYVLNLTK 105
            ..|  |:..|:.:     .||.:  |....:...|  .|.|           ||.|..:    .|
Mouse    71 SINFEIYSAPLSKDDLEYAFEKWVGNWTYELKKLP--FWTSYSKLQKISSEYSDMIESF----CK 129

  Fly   106 TVLNNEGVRRDILGPQKPHFDLVIMDLWRMDVLSG--LAAYFDAPIIGMASYGTDWKIDELMGNV 168
            .|:.|:.:.:.:.|.:   ||:|:.|..   |..|  |:.....|::....:...:|.::..|.:
Mouse   130 AVVWNKSLMKKLQGSK---FDVVLADAL---VPCGELLSELLKTPLVYSLRFCPGYKCEKYSGGL 188

  Fly   169 S-PISYLQSPSSRFYDLEAYGERLLHLME--------RTFSYMNYKWRHVRKQETLYSQFFPSVA 224
            . |.||:....|...|...:.||:.::::        :||:            |..::||:..|.
Mouse   189 PLPPSYVPVVLSELSDHMTFAERVKNMLQVLLFDFWFQTFN------------EKSWNQFYSDVL 241

  Fly   225 ER-KPLSEISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGV 288
            .| ..|:|:....|:.||...:.|..|.|::||...|||||. ...:.|..|::.|:|.:||.||
Mouse   242 GRPTTLTEMMGKADIWLVRTFWDLKFPHPFLPNFDFVGGLHC-KPAKPLPKEMEEFVQSSGEHGV 305

  Fly   289 IYFSLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPP-----NVFISKWFPQQAI 348
            :.||||:.|  |::.|::..|:....|.:||:::|:|:     ||.|     |..:.||.||..:
Mouse   306 VVFSLGSMV--KNIKEEKANVVASALAQIPQKVLWRFD-----GKKPDTLGSNTRLYKWIPQNDL 363

  Fly   349 LAHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRS 413
            |.||..|.||.|||.....|:|:||.|::|:|...||..|::|:...|..:.::...|::.:..:
Mouse   364 LGHPKTKAFIAHGGTNGIYEAIYHGIPIVGIPLFGDQPDNINHIVAKGAAVRVDFDTMSTTDLLT 428

  Fly   414 TIIRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLD 478
            .:..::.:.|::|.|...:..:.||||||::.|::|.|||:.:|||.|::.|..||.:.:|||||
Mouse   429 ALKTVINDPSYKENAMRLSRIHHDQPMKPLDRAVFWIEYVMRNKGAKHLRPALHDLTWFQYHSLD 493

  Fly   479 VFGTFLVGALVILGIVTYLLVMTLRKCLF 507
            |.|..||..:.::.|:.       :.|||
Mouse   494 VIGFLLVCVVAVVFIIA-------KCCLF 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	141/502 (28%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	150/521 (29%)
Ugt2b1	NP_690024.1	egt	8..508	CDD:223071	154/533 (29%)
Ugt2b1	NP_690024.1	UDPGT	24..527	CDD:278624	153/533 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840420
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690