DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and ugt5c3

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001122186.1	Gene:	ugt5c3 / 563413	ZFINID:	ZDB-GENE-050419-23	Length:	531	Species:	Danio rerio

Alignment Length:	568	Identity:	142/568 - (25%)
Similarity:	268/568 - (47%)	Gaps:	108/568 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPPIFLLVC-------LLPGYS---EGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPY 55
            |.|:|..:|       ::|.:.   :|.:||.| || ..||:......:|:|...||.|
Zfish     1 MAPLFKNLCSVSLWITIIPLFGFLCDGGKILVV-PL-EGSHWLNMDILIKALHGKGHSI------ 57

  Fly    56 PQREPFRNIHDIPVPEVFENFNEVLRIASTPRSTWQSSDFINE---------------------- 98
               :..||.:...|.|..:.:|.:    :.|:|.....:|:::
Zfish    58 ---DVIRNTNSWYVKEKSDYYNSI----TIPQSKGMDEEFVDDMISKVINHERGKSSWLSTVKLF 115

  Fly    99 ------------YVLNLTKTVLNNEGVRRDILGPQKPHFDLVIMD-LWRMDVLSGLAAYFDAPII 150
                        .|.::|.::..:|.:.:.:   |:..:||::.| :|.|.::  ||.....|::
Zfish   116 FDSVIDNYEMTKMVCDITTSIFESEEILKTL---QEKQYDLMLTDPVWGMGII--LAHKLKLPMV 175

  Fly   151 GMASYGTDW--KIDELMGNV--SPISYLQSPSSRFYDLEAYGERLLHLMERTFSYMNYKWRHVRK 211
                |...|  .:|... |:  ||:||:....|...|..::.:|:.:::   |.:.|
Zfish   176 ----YNVRWTTTVDGHF-NIAPSPMSYIPITGSGNTDRMSFFQRVKNII---FYFTN-------- 224

  Fly   212 QETLYSQF----FPSVAER---KPLS--EISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDH 267
             :..||:|    :.::.::   .|:.  ::.:..|:.|:...|....|||.:||:|..||....
Zfish   225 -DIKYSRFSLPQYQAICDKYFDPPVDFYQLLQGADIWLMRVDFVFEFPRPTMPNIIYTGGFQCT- 287

  Fly   268 STEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPG 332
            ..:.|..:|:.|:|.:|:.|||..||||.:  .:|.||....:...||.|||:::|::     .|
Zfish   288 PAKPLPHDLEDFMQSSGDHGVIVMSLGTFI--SALPEDVTAEIAAAFARLPQKVIWRY-----TG 345

  Fly   333 KPP-----NVFISKWFPQQAILAHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHV 392
            |.|     |..:..|.||:.:|.||..|:|:.|||.....|:::||.|::|:|..|||:.|:..:
Zfish   346 KKPSTLGNNTLLVDWMPQKDLLGHPKTKVFVAHGGTNGVQEALYHGVPVVGIPFFFDQYDNLIRL 410

  Fly   393 RQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHK 457
            :..|...::::.::......:.|..::.|.|:..|.:..:..:.|:|:||:::||:|.|:|:.||
Zfish   411 QARGGAKIVSLAELGENSLHAAIKEVINNPSYRLTMQKLSQLHLDKPVKPLDSAIFWIEFVMRHK 475

  Fly   458 GAAHMQVAGKDLGFVRYHSLDVFGTFLVGALVILGIVTYLLVMTLRKC 505
            ||||::.....:.:..|||:||..|.:...|:.:..:.|::.....||
Zfish   476 GAAHLRTESYKMPWYSYHSVDVAVTLIAVVLIFIFSIFYVVRYVCIKC 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	131/523 (25%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	131/529 (25%)
ugt5c3	NP_001122186.1	UDPGT	28..530	CDD:278624	136/541 (25%)
ugt5c3	NP_001122186.1	egt	<267..507	CDD:223071	80/247 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585083
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.690