DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and ugt2a2

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001018306.2	Gene:	ugt2a2 / 553952	ZFINID:	ZDB-GENE-080721-21	Length:	534	Species:	Danio rerio

Alignment Length:	552	Identity:	153/552 - (27%)
Similarity:	258/552 - (46%)	Gaps:	81/552 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPPIFLLVCLLPGYSEGARILAVFPLPSS-SHYFFALPYLKSLASLGHEIT----SVSP---YPQ 57
            :.|..|::..:..::....:|.   ||.. ||:......:..|.:..|.:|    |.||   :.|
Zfish     6 LKPSPLVLIFIFSFTHAGNVLV---LPGEYSHWQNMRNVVDELLNRNHTVTVLVCSASPTINFTQ 67

  Fly    58 REPFRNIHDIPVPEVFENFNEVLRIASTPRSTWQSSDFINEYVL---------NLTKTVLN---- 109
            :|.|:.:       |||          .|.|. |..|..:|.::         |..:|.|.
Zfish    68 QERFQYL-------VFE----------VPLSA-QELDGASEELIHIWTQHPSPNRLQTALQIIEL 114

  Fly   110 ------------NEGVRRDILGPQKP--HFDLVIMDLWRM--DVLSGLAAYFDAPIIGMASYGTD 158
                        :..:|.|.|..|..  .||::..|...|  |:   ||.....|::........
Zfish   115 LGRVRVMHRAMCDSMLRNDALIAQLSALKFDVLFNDPMFMCADL---LAEMLGLPLVLSVRISPG 176

  Fly   159 WKIDELMGNV-SPISYLQSPSSRFYDLEAYGERLLHLMER-TFSYMNY--KWRHVRKQETLYSQF 219
            :.::.:.|.: :|.|::....:...|...:.||:.:::.. .||...|  .|      .:|.|.:
Zfish   177 FCLERMCGQMPAPPSFVPITQTVLTDRMCFMERVQNMIANIVFSVSFYIVAW------ISLDSYY 235

  Fly   220 FPSVAERKPLSEISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAG 284
            ...:.:...:.|.....|:.|:..::....|||:.||...|||||. ...:.||.|::.|:|.:|
Zfish   236 TDVLGKPTTMCETMGKADIWLIRTYWDFEYPRPFPPNFKFVGGLHC-KPAKPLSKEMEEFVQSSG 299

  Fly   285 ESGVIYFSLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPPNVFISKWFPQQAIL 349
            :.||:.||||:.:  |:|:.:|...:......:||::||::..:......||..|..|.||..:|
Zfish   300 DHGVVVFSLGSMI--KNLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDWIPQNDLL 362

  Fly   350 AHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRST 414
            .||..|.||||||.....|:|:||.||:|||...||..|:.|::..|..:||:|..:.|::....
Zfish   363 GHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKDLVDA 427

  Fly   415 IIRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDV 479
            :..:|.|.|::|:....:..:.||||||::.|::|.|:|:.:|||.|::|...:|.:.:||.|||
Zfish   428 LKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDV 492

  Fly   480 FGTFLVGALVILGIVTYLLVMTLRKCLFLIKR 511
             ..||   |.|..::|:|.|   :.|.||.:|
Zfish   493 -AAFL---LSIAALITFLWV---KACCFLFRR 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	134/501 (27%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	147/520 (28%)
ugt2a2	NP_001018306.2	UDPGT	23..521	CDD:278624	151/535 (28%)
ugt2a2	NP_001018306.2	egt	<256..487	CDD:223071	84/233 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H55988
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	10	9.860