DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and ugt8

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001037790.2	Gene:	ugt8 / 553508	ZFINID:	ZDB-GENE-060616-129	Length:	541	Species:	Danio rerio

Alignment Length:	530	Identity:	142/530 - (26%)
Similarity:	262/530 - (49%)	Gaps:	55/530 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLVCLLPGYSEGARILAVFPLPSSSH-YFFALPYLKSLASL----GHE-ITSVSPYPQREPFRNI 64
            ||.||....|..|:|:.|.|:...|| |.|     |:|||.    ||: :..||...:..|..:.
Zfish    10 LLWCLATSLSWAAKIVVVPPIMFESHLYIF-----KTLASALHAEGHDTVFLVSEGREIPPSNHY 69

  Fly    65 HDIPVPEVF-----ENF--NEVLRIASTPRSTWQSSDFINEYVLNLTKTVLNNEGVRRDILGPQK 122
            .....|.:|     ::|  ::|..|.|...:..:..|.::.|..| ...|:.:..|...:   ::
Zfish    70 RLQRYPGIFNSTSADDFLQSKVRNIFSGRLTALELFDILDHYSQN-CDAVVGSTSVMEQL---KR 130

  Fly   123 PHFDLVIMDLWRMDVLSGLAAYFDAPIIGM--ASYGTDWKIDELMGNVSPISYLQSPSSRFYDLE 185
            .||||:::|      .:.:..:..|.|:|:  |.:.|.......:|..:|:||:...:|...|..
Zfish   131 EHFDLLLVD------PNEMCGFVIAHILGVQYAVFSTGLWYPAEVGAPAPLSYVPEFNSLLTDHM 189

  Fly   186 AYGERLLHLMERTFSYMNYKWRHVRKQETLYSQF--FPSVAERKPLSEISRNFDLVLVNQHFTLG 248
            :..:|:.:......|....::..:.|.:.:..::  .|||:    :.::.:|..|.::.....|.
Zfish   190 SLFQRVANTAVYLVSRFGVQFLVLPKYDRIMRKYNIQPSVS----MHDLVQNSRLWMLCTDMALE 250

  Fly   249 PPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDRRKVLLET 313
            .|||.:|:::.|||: :......|..|.:.:::...|.|.:..|.|..|  |.||:|..:.|...
Zfish   251 FPRPTLPHVVYVGGI-LTKPPSPLPQEFETWVKDTDEDGFVVVSFGAGV--KYLSDDIAQKLAGA 312

  Fly   314 FASLPQRIVWKFEDELLPGKPP-----NVFISKWFPQQAILAHPNVKLFITHGGLLSTIESIHHG 373
            .:.||||::|:|.     |.||     |..:..|.||..:|...|.:.|::||||.|..|:::||
Zfish   313 LSRLPQRVIWRFS-----GVPPSNLGNNTKLVDWMPQNDLLGQTNTRAFLSHGGLNSIYEAMYHG 372

  Fly   374 KPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARYRDQ 438
            .|::|:|...|.:..|..|:..|:|::|..|:|:.|:..:.::.::|:|.:.|.|::.:..::||
Zfish   373 VPVVGVPLFGDHYDTMTRVQAKGMGIMLEWKRMSEEDLYTAMVNVITDKRYRERAQLLSQIHKDQ 437

  Fly   439 PMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVG-ALVILGIVTYLLVMTL 502
            |..|:..|::|..|:|.|:||.|::.|..::...:|..|||  ..::| .|::.|...|.:|..:
Zfish   438 PGHPVSRAVYWISYILRHRGAEHLRSAVYEIPTYQYFLLDV--AMVIGVCLLLTGYCLYRIVKFI 500

  Fly   503 RKCLFLIKRG 512
            :   |.:.||
Zfish   501 Q---FRLGRG 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	128/477 (27%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	131/503 (26%)
ugt8	NP_001037790.2	UDPGT	22..500	CDD:330975	134/506 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585173
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.740