DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and Ugt2a2

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001019319.1	Gene:	Ugt2a2 / 552899	MGIID:	3576095	Length:	528	Species:	Mus musculus

Alignment Length:	528	Identity:	151/528 - (28%)
Similarity:	267/528 - (50%)	Gaps:	54/528 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LAVFPLPSSSHYFFALPYLKSLASLGHEITSVSP------YPQREPFRNIHDIPVPEVFENFNEV 79
            :.|:| ...||:......|:.|....|.:|.::|      ..:.:.|.|..:|||.......:|:
Mouse    24 VVVWP-TDGSHWLNIKILLEELVQRNHSVTVLAPSETLFINSRLDAFINFEEIPVSYTKSKIDEI 87

  Fly    80 LR--IA------STPRSTWQSSDFINE--------YVLN--LTKTVLNNEGVRRDILGPQKPHFD 126
            :.  ||      .||.:.|   .|..|        |..|  :...||||..|...:   ||..||
Mouse    88 IEHMIALWLDHRPTPLTMW---TFYKELGNLLATFYTTNKQMCDGVLNNPTVMERL---QKGGFD 146

  Fly   127 LVIMDLWRMDVLSG--LAAYFDAPIIGMASYGTDWKIDELMGNV-SPISYLQSPSSRFYDLEAYG 188
            :::.|...|   .|  :|.....|.:....:...:.::...|.: :||||:.:..|...|..::|
Mouse   147 VLLADPVTM---CGELVALKLGIPFVYTLRFSPAFTVERHCGKIPAPISYVPAALSELTDQMSFG 208

  Fly   189 ERLLHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAER-KPLSEISRNFDLVLVNQHFTLGPPRP 252
            ||:.:::  ::|..:|.::....:   ::.::..|..| ..|.|.....::.|:..::....|||
Mouse   209 ERVKNII--SYSLQDYIFKTYWGE---WNSYYSKVLGRPTTLCETMGKAEIWLMRTYWDFEFPRP 268

  Fly   253 YVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDRRKVLLETFASL 317
            |:||...|||||. ...:.|..|::.|:|.:||.|::.||||:.|  |:|::::..::....|.:
Mouse   269 YLPNFEFVGGLHC-KPAKPLPKEMEEFVQTSGEHGIVVFSLGSMV--KNLTDEKANLIASALAQI 330

  Fly   318 PQRIVWKFEDELLPGKPPNVFISKWFPQQAILAHPNVKLFITHGGLLSTIESIHHGKPMLGLPCL 382
            ||:::|:::.::......|..:..|.||..:|.||..:.||||||.....|:|:||.||:|:|..
Mouse   331 PQKVLWRYKGKIPDTLGSNTRLFDWIPQNDLLGHPKTRAFITHGGTNGIYEAIYHGIPMVGVPMF 395

  Fly   383 FDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARYRDQPMKPMETAI 447
            .||..|:.|::..|..:.:|:..|||.:..:.:..::...|::|.|...:..:.|||:||::.|:
Mouse   396 ADQPDNIAHMKAKGAAVEVNMNTMTSSDLLNALRTVINEPSYKENAMRLSRIHHDQPVKPLDRAV 460

  Fly   448 WWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALVILGIVTYLLVMTLRKCLFLIKR- 511
            :|.|:|:.||||.|::||..||.:.:||||||.|       .:|..|...:::..:.|||:.::
Mouse   461 FWIEFVMRHKGAKHLRVAAHDLSWFQYHSLDVIG-------FLLACVASAILLVAKCCLFIFQKV 518

  Fly   512 GKCEAIKK 519
            ||....||
Mouse   519 GKTGKKKK 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	130/468 (28%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	145/508 (29%)
Ugt2a2	NP_001019319.1	UDPGT	22..516	CDD:278624	147/516 (28%)
Ugt2a2	NP_001019319.1	egt	<267..487	CDD:223071	79/222 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840198
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.790