Protein Alignment Ugt35D1 and UGT1A5

DIOPT Version :9

• Sequence 1: NP_651866.1
• Gene: Ugt35D1 / 43708
• FlyBaseID: FBgn0051002
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_061951.1
• Gene: UGT1A5 / 54579
• HGNCID: 12537
• Length: 534
• Species: Homo sapiens
• Alignment Length: 566
• Identity: 149/566 - (26%)
• Similarity: 265/566 - (46%)
• Gaps: 104/566 - (18%)

  Fly     4 IFLLVCLLPGYSEGARILAVFPLPS-SSHYFFALPYLKSLASLGHEIT----SVSPYPQREPFRN 63
            :.||:.:.| ::|..::|.|   |: .||:......|:.|.:.||::.    .|:.|.:.|.|..
Human    16 LLLLLSVQP-WAESGKVLVV---PTDGSHWLSMREALRDLHARGHQVVVLTLEVNMYIKEENFFT 76

  Fly    64 IHDIPVPEVFENFNEVLRIASTPRSTWQSSDFINEYVL-----------NLTKTV-------LNN 110
            :....:....:.|:.:| :..|      .|.|..|::|           |::..:       |:|
Human    77 LTTYAISWTQDEFDRLL-LGHT------QSFFETEHLLMKFSRRMAIMNNMSLIIHRSCVELLHN 134

  Fly   111 EGVRRDILGPQKPHFDLVIMDLWRMDVLSGLAAYFDAPII------------------GMASYGT 157
            |.:.|.:   ....||:|:.|.:.: ..:.||.|...|.:                  ..:||
Human   135 EALIRHL---HATSFDVVLTDPFHL-CAAVLAKYLSIPAVFFLRNIPCDLDFKGTQCPNPSSY-- 193

  Fly   158 DWKIDELM-GNVSPISYLQSPSSRFYDLE-AYGERLLHLMERTFSYMNYKWRHVRKQETLYSQFF 220
               |..|: .|...:::||...:..|.|. :|   |.|.:...::             :|.|:.|
Human   194 ---IPRLLTTNSDHMTFLQRVKNMLYPLALSY---LCHAVSAPYA-------------SLASELF 239

  Fly   221 PSVAERKPLSEISRNFDLV------LVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHF 279
                 ::.:|.:    |||      |....|.:..|||.:|||:.:||::..:. :.||.|.:.:
Human   240 -----QREVSVV----DLVSHASVWLFRGDFVMDYPRPIMPNMVFIGGINCANG-KPLSQEFEAY 294

  Fly   280 IQGAGESGVIYFSLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPPNVFISKWFP 344
            |..:||.|::.||||:.|  ..:.|.:...:.:....:||.::|::..........|..:.||.|
Human   295 INASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLP 357

  Fly   345 QQAILAHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSE 409
            |..:|.||..:.||||.|.....|||.:|.||:.:|...||..|...:...|.|:.||:.:||||
Human   358 QNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSE 422

  Fly   410 EFRSTIIRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRY 474
            :..:.:..::.:||::|.....::.::|:|::|::.|::|.|:|:.||||.|::.|..||.:.:|
Human   423 DLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQY 487

  Fly   475 HSLDVFGTFLVGALVILGIVTY-LLVMTLRKCLFLIKRGKCEAIKK 519
            |||||.| ||:..::.:..:|: ......||||     ||...:||
Human   488 HSLDVIG-FLLAVVLTVAFITFKCCAYGYRKCL-----GKKGRVKK 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	127/506 (25%)
		UDPGT	30..511	CDD:278624	138/529 (26%)
UGT1A5	NP_061951.1	UDPGT	29..525	CDD:278624	143/548 (26%)
		egt	<262..508	CDD:223071	82/249 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150577
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8458
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	9	8.790