Protein Alignment Ugt35D1 and UGT1A7

DIOPT Version :10

• Sequence 1: NP_651866.1
• Gene: Ugt35D1 / 43708
• FlyBaseID: FBgn0051002
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_061950.2
• Gene: UGT1A7 / 54577
• HGNCID: 12539
• Length: 530
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 149/546 - (27%)
• Similarity: 263/546 - (48%)
• Gaps: 62/546 - (11%)

  Fly     3 PIFLLVCLLPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRNIH-- 65
            |:::.:.|..|:::..::|.| |: ..||:|.....::.|...|||:..|.|....:..|:::
Human    11 PLYVCLLLTCGFAKAGKLLVV-PM-DGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGRSLNCT 73

  Fly    66 --DIPVPEVFENFNEVLRIASTPRST----------WQSSDFINEYVLNLTKTVLNNEGVRRDIL 118
              ........|:.:....:.:..|.|          ..||:.|.:...:..:::.|:   |:.:.
Human    74 VKTYSTSYTLEDQDREFMVFADARWTAPLRSAFSLLTSSSNGIFDLFFSNCRSLFND---RKLVE 135

  Fly   119 GPQKPHFDLVIMDLWRMDVLSGL--AAYFDAPIIGMASYGTDWKIDELMGNVSPISYLQSPSSRF 181
            ..::..||.|.:|.:.   ..||  |.||..|.:..|.......::|.....:|:||:......|
Human   136 YLKESCFDAVFLDPFD---ACGLIVAKYFSLPSVVFARGIFCHYLEEGAQCPAPLSYVPRLLLGF 197

  Fly   182 YDLEAYGERLLHLMERTFSYMNYKWRHV-RKQETLY-SQFFPSVAERKPLSEISRN----FDLV- 239
            .|...:.||:              |.|: ..:|.|: ..||.:|.|  ..|||.:.    :||.
Human   198 SDAMTFKERV--------------WNHIMHLEEHLFCPYFFKNVLE--IASEILQTPVTAYDLYS 246

  Fly   240 -----LVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKS 299
                 |:...|.|..|:|.:||||.:||::. |..:.:..|.:.:|..:||.|::.||||:.|
Human   247 HTSIWLLRTDFVLEYPKPVMPNMIFIGGINC-HQGKPVPMEFEAYINASGEHGIVVFSLGSMV-- 308

  Fly   300 KSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPPNVFISKWFPQQAILAHPNVKLFITHGGLL 364
            ..:.|.:...:.:....:||.::|::..........|..:.||.||..:|.||..:.||||.|..
Human   309 SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSH 373

  Fly   365 STIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETAR 429
            ...|||.:|.||:.:|...||..|...:...|.|:.||:.:||||:..:.:..::.:||::|...
Human   374 GVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIM 438

  Fly   430 ITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALVILGIV 494
            ..::.::|:|::|::.|::|.|:|:.||||.|::.|..||.:.:||||||.| ||:..::.:..:
Human   439 RLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIG-FLLAVVLTVAFI 502

  Fly   495 TY-LLVMTLRKCLFLIKRGKCEAIKK 519
            |: ......||||     ||...:||
Human   503 TFKCCAYGYRKCL-----GKKGRVKK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	GT1_Gtf-like	18..449	CDD:340817	117/458 (26%)
UGT1A7	NP_061950.2	UDPGT	26..521	CDD:278624	144/527 (27%)