Protein Alignment Ugt35D1 and UGT1A8

DIOPT Version :9

• Sequence 1: NP_651866.1
• Gene: Ugt35D1 / 43708
• FlyBaseID: FBgn0051002
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_061949.3
• Gene: UGT1A8 / 54576
• HGNCID: 12540
• Length: 530
• Species: Homo sapiens
• Alignment Length: 568
• Identity: 158/568 - (27%)
• Similarity: 265/568 - (46%)
• Gaps: 104/568 - (18%)

  Fly     3 PIFLLVCLL--PGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRNIH 65
            ||.|.|.||  .|::|..::|.| |: ..||:|.....::.|...|||:..|
Human     9 PIPLCVSLLLTCGFAEAGKLLVV-PM-DGSHWFTMQSVVEKLILRGHEVVVV------------- 58

  Fly    66 DIPVPEVFENFNEVLRIASTPRST------------------WQ-------------SSDFINEY 99
               :|||.....:.|.......||                  |:             |:.|.|.:
Human    59 ---MPEVSWQLGKSLNCTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLF 120

  Fly   100 VLNLTKTVLNNEGVRRDILGPQKPHFDLVIMDLWRMDVLSGL--AAYFDAPII----GMASYGTD 158
             .:..:::.|:   |:.:...::..||.|.:|.:.   ..||  |.||..|.:    |:|.:
Human   121 -FSHCRSLFND---RKLVEYLKESSFDAVFLDPFD---ACGLIVAKYFSLPSVVFARGIACH--- 175

  Fly   159 WKIDELMGNVSPISYLQSPSSRFYDLEAYGERLL-HLMERTFSYMNYKWRHVRKQETLYSQFFPS 222
             .::|.....:|:||:......|.|...:.||:. |:|            |:  :|.|:.|:|..
Human   176 -YLEEGAQCPAPLSYVPRILLGFSDAMTFKERVRNHIM------------HL--EEHLFCQYFSK 225

  Fly   223 VAERKPLSEISRN----FDLV------LVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELD 277
            .| .:..|||.:.    :||.      |:...|.|..|:|.:||||.:||::. |..:.|..|.:
Human   226 NA-LEIASEILQTPVTAYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINC-HQGKPLPMEFE 288

  Fly   278 HFIQGAGESGVIYFSLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPPNVFISKW 342
            .:|..:||.|::.||||:.|  ..:.|.:...:.:....:||.::|::..........|..:.||
Human   289 AYINASGEHGIVVFSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKW 351

  Fly   343 FPQQAILAHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMT 407
            .||..:|.||..:.||||.|.....|||.:|.||:.:|...||..|...:...|.|:.||:.:||
Human   352 LPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMT 416

  Fly   408 SEEFRSTIIRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFV 472
            ||:..:.:..::.:||::|.....::.::|:|::|::.|::|.|:|:.||||.|::.|..||.:.
Human   417 SEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWY 481

  Fly   473 RYHSLDVFGTFLVGALVILGIVTY-LLVMTLRKCLFLIKRGKCEAIKK 519
            :||||||.| ||:..::.:..:|: ......||||     ||...:||
Human   482 QYHSLDVIG-FLLAVVLTVAFITFKCCAYGYRKCL-----GKKGRVKK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	136/508 (27%)
		UDPGT	30..511	CDD:278624	143/529 (27%)
UGT1A8	NP_061949.3	UDPGT	26..521	CDD:278624	148/547 (27%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165150339
Domainoid	1	1.000	260	1.000	Domainoid score	I1978
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	267	1.000	Inparanoid score	I3041
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8458
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.690