Protein Alignment Ugt35D1 and UGT1A10

DIOPT Version :10

• Sequence 1: NP_651866.1
• Gene: Ugt35D1 / 43708
• FlyBaseID: FBgn0051002
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_061948.1
• Gene: UGT1A10 / 54575
• HGNCID: 12531
• Length: 530
• Species: Homo sapiens
• Alignment Length: 555
• Identity: 154/555 - (27%)
• Similarity: 269/555 - (48%)
• Gaps: 78/555 - (14%)

  Fly     3 PIFLLVCLL--PGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRNIH 65
            |:.|.||||  .|::|..::|.| |: ..||:|.....::.|...|||:..|.|....:..|:::
Human     9 PVPLCVCLLLTCGFAEAGKLLVV-PM-DGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLERSLN 71

  Fly    66 ----DIPVPEVFENFNEVLRIASTPRSTWQ-------------SSDFINEYVLNLTKTVLNNEGV 113
                ........|:.|....:.:  .:.|:             ||.|::.: .:..:::.|:
Human    72 CTVKTYSTSYTLEDQNREFMVFA--HAQWKAQAQSIFSLLMSSSSGFLDLF-FSHCRSLFND--- 130

  Fly   114 RRDILGPQKPHFDLVIMDLWRMDVLSGL--AAYFDAPII----GMASYGTDWKIDELMGNVSPIS 172
            |:.:...::..||.|.:|.:.   ..||  |.||..|.:    |:..:    .::|.....:|:|
Human   131 RKLVEYLKESSFDAVFLDPFD---TCGLIVAKYFSLPSVVFTRGIFCH----HLEEGAQCPAPLS 188

  Fly   173 YLQSPSSRFYDLEAYGERLLHLMERTFSYMNYKWRH-VRKQETLYSQF-FPSVAERKPLSEISRN 235
            |:.:....|.|...:.||:              |.| |..::.|:.|: |.:..|  ..|||.:.
Human   189 YVPNDLLGFSDAMTFKERV--------------WNHIVHLEDHLFCQYLFRNALE--IASEILQT 237

  Fly   236 ----FDLV------LVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIY 290
                :||.      |:...|.|..|:|.:||||.:||::. |..:.|..|.:.:|..:||.|::.
Human   238 PVTAYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINC-HQGKPLPMEFEAYINASGEHGIVV 301

  Fly   291 FSLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPPNVFISKWFPQQAILAHPNVK 355
            ||||:.|  ..:.|.:...:.:....:||.::|::..........|..:.||.||..:|.||..:
Human   302 FSLGSMV--SEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTR 364

  Fly   356 LFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLT 420
            .||||.|.....|||.:|.||:.:|...||..|...:...|.|:.||:.:||||:..:.:..::.
Human   365 AFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVIN 429

  Fly   421 NKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLV 485
            :||::|.....::.::|:|::|::.|::|.|:|:.||||.|::.|..||.:.:||||||.| ||:
Human   430 DKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIG-FLL 493

  Fly   486 GALVILGIVTY-LLVMTLRKCLFLIKRGKCEAIKK 519
            ..::.:..:|: ......||||     ||...:||
Human   494 AVVLTVAFITFKCCAYGYRKCL-----GKKGRVKK 523

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	GT1_Gtf-like	18..449	CDD:340817	117/465 (25%)
UGT1A10	NP_061948.1	UDPGT	26..521	CDD:278624	144/534 (27%)