DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35D1 and Ugt37C2

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001260516.1	Gene:	Ugt37C2 / 53513	FlyBaseID:	FBgn0040262	Length:	523	Species:	Drosophila melanogaster

Alignment Length:	520	Identity:	153/520 - (29%)
Similarity:	257/520 - (49%)	Gaps:	46/520 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IFLLVCLLPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRNIHDIP 68
            :|||:..:...::||.||.:|...|.||....:...|:|...||.:|.||....:...::||.|.
  Fly     7 VFLLLLGVVASTQGANILGLFSSHSPSHLIIHMSVAKALVKAGHNVTVVSMLKPKVTHKDIHLIV 71

  Fly    69 VPEVFENFNEVLRIASTPRSTWQSSDFINEYVLNLTKTVLNNEGVRRDILGPQK------PHFDL 127
            || :.|....::....|..:..::|.....|.|..:..|:.|  .:.::|...:      ..|||
  Fly    72 VP-MKEEQERIMEDQMTEMAGQKNSLVSTMYRLLTSMDVMIN--AQAELLSDPRFQRIYETKFDL 133

  Fly   128 VIMDLWRMDVLSGLAAYFDAPIIGMASYGTDW------KIDELMGNVSPISYLQSPSSRFYDLEA 186
            :|:..:..|...|:|.....|:|      .:|      .||:..||.|.:||:  |.......:.
  Fly   134 MILGYFINDFQLGVAHKLKVPVI------INWMSAPVPAIDKYTGNPSELSYV--PLMGTVATQP 190

  Fly   187 YG-----ERLLH--LMERTFSYMNYKWRHVRKQETLYSQFFPSVAERKPLSEISRNFDLVLVNQH 244
            .|     |..|.  |.|..|...:||...:      |:..||. .:...|.|:.:|..:..|..|
  Fly   191 MGFLKRTENALKSLLFEFIFVVFDYKLTRI------YNDVFPE-QDMPTLKELRKNISMAFVGSH 248

  Fly   245 -FTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDRRK 308
             .:.||.||.||.:|::||:.|....:.|..::|.||..| :.|.::.|||:||||.::..:..:
  Fly   249 LISEGPIRPLVPALIEIGGIQVKDKPDPLPKDIDQFISNA-KQGAVFLSLGSNVKSSTVRPEIVQ 312

  Fly   309 VLLETFASLPQRIVWKFED-ELLPGKPPNVFISKWFPQQAILAHPNVKLFITHGGLLSTIESIHH 372
            ::.:..:.|.:.::||:|| |..||...|:....|.||..||||||.||||||.|.....|:.:|
  Fly   313 IIFKVLSELKENVIWKWEDLENTPGNSSNILYKNWLPQDDILAHPNTKLFITHAGKGGITEAQYH 377

  Fly   373 GKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARYRD 437
            |.||:.||...||..|...:.:.|.||.|::..:|.:..|..:..:|.|:.:::.....:..|||
  Fly   378 GVPMVALPIFGDQPGNAALMEKSGYGLALDLLSITEDSLRDALKEVLENQKYKQAIGQFSTLYRD 442

  Fly   438 QPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALVILGIVTYLLVMTL 502
            :||...::.::||||:|.|:||.::|.....:.|::.::||::      ||::..:|.::|:..|
  Fly   443 RPMTAKQSVVFWTEYILRHQGAPNLQSPSVHMNFIQLNNLDIY------ALIVTILVLFVLLTRL 501

Fly 503 502
Fly 502 501

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	144/478 (30%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	144/494 (29%)
Ugt37C2	NP_001260516.1	egt	1..467	CDD:223071	144/478 (30%)
Ugt37C2	NP_001260516.1	UDPGT	33..515	CDD:278624	144/494 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445694
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	9	8.850