DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and Ugt302C1

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_652626.1	Gene:	Ugt302C1 / 53510	FlyBaseID:	FBgn0040259	Length:	528	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	199/511 - (38%)
Similarity:	305/511 - (59%)	Gaps:	26/511 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLVCLLPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRNIHDIPVP 70
            ||.|||...| ....|.|....:.|||.......|.||:.||::|.:||:..::|.:||.|:|..
  Fly    14 LLFCLLSCVS-AYNYLVVLHTAARSHYHVGSALAKGLAAAGHQVTIISPFELKKPIKNIKDVPAK 77

  Fly    71 EVFENFNEVLRIASTPRSTWQS--SDFIN--EYVLNLTKTVLNNEGVRRDILGPQKPHFDLVIMD 131
            .:..:...  |||:..:|:.:.  ...||  |..:.:|:.:|....|..  |......||.||.:
  Fly    78 SILTSMQG--RIANLLQSSKEPIIKQIINFHEMGIEITELLLKEPSVIE--LMKSNQTFDAVISE 138

  Fly   132 LWRMDVLSGLAAYFDAPIIGMASYGT-DWKIDELMGNVSPISYLQSPSSRFYDLEAYGERLLHLM 195
            ::..:...|.|.:|.||:||:.::|. .|..| |:|:.||.||:.|...:|.|..:..||:.:..
  Fly   139 VFLNEAHFGFAEHFKAPLIGLGTFGAISWNTD-LVGSPSPPSYVPSALLKFSDRMSLVERVGNQA 202

  Fly   196 ERTFSYMNYKWRHVRKQETLYSQFFPSVAERKPLSEISRNFDLVLVNQHFTLGPPRPYVPNMIQV 260
            ..|:.|:...:.::.:||.||.::||:  .::...::.:|..|||:|||.:|..||||.||||:|
  Fly   203 FLTYEYIFLNYFYLPRQEVLYRKYFPN--NKQDFYDMRKNTALVLLNQHVSLSFPRPYSPNMIEV 265

  Fly   261 GGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKF 325
            ||:|::...:.|..::..||:|| |.||||||:|:|:|||:|..::|:.|::|||.|.||::|||
  Fly   266 GGMHINRKRQPLPKDILEFIEGA-EHGVIYFSMGSNLKSKTLPLEKRQALIDTFAQLKQRVLWKF 329

  Fly   326 EDELLPGKPPNVFISKWFPQQAILAHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMD 390
            ||..|||||.|||||.||||..||||.||..||||||||||.|||:|.||.:|:|...|||.||.
  Fly   330 EDTDLPGKPANVFISDWFPQDDILAHDNVLAFITHGGLLSTTESIYHRKPFVGIPIFGDQFLNMA 394

  Fly   391 HVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLS 455
            ...|.|.|:.::.::::|.:..:.|.:::.|....:..|..:.|||||...|:|.|::|.|:|..
  Fly   395 RAEQNGYGVTVHYEELSSAKLLAAIQKIINNPEATQRVRDMSDRYRDQQQTPLERAVYWVEHVSR 459

  Fly   456 HKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALVILGIVTYLLVMTLRKCLFLIKR 511
            ||||.:::.|.:||.|::||:||..       |::.|.:.::|.     |:||:.|
  Fly   460 HKGAKYLRSASQDLNFIQYHNLDAM-------LILYGGIIFVLY-----CIFLLIR 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	184/460 (40%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	190/485 (39%)
Ugt302C1	NP_652626.1	egt	<117..466	CDD:223071	152/354 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445631
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.800