DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and Ugt8

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_062149.1	Gene:	Ugt8 / 50555	RGDID:	3938	Length:	541	Species:	Rattus norvegicus

Alignment Length:	529	Identity:	140/529 - (26%)
Similarity:	249/529 - (47%)	Gaps:	45/529 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 PIFLLVCLLPGYSEGARILAVFPLPSSSH-YFFALPYLKSLASLGHE-----ITSVSPYPQREPF 61
            |.|:|:....|.:..|:|:.|.|:...|| |.|     |:|||..||     :..:|.....:|.
  Rat     6 PYFMLLWSAVGIARAAKIIIVPPIMFESHLYIF-----KTLASALHERGHHTVFLLSEGRDIDPS 65

  Fly    62 RNIHDIPVPEVFENFNEVLRIASTPRSTWQSS-------DFINEYVLNLTKTVLNNEGVRRDILG 119
            .:......|.:|.:......:.|..|:.:...       |.::.|..|....| .|:.:   |.|
  Rat    66 NHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAVELVDILDHYTKNCDMMV-GNQAL---IQG 126

  Fly   120 PQKPHFDLVIMDLWRMDVLSGLAAYFDAPIIGM--ASYGTDWKIDELMGNVSPISYLQSPSSRFY 182
            .:|..|||:::|      .:.:..:..|.::|:  |.:.|.......:|..:|::|:...:|...
  Rat   127 LKKEKFDLLLVD------PNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLT 185

  Fly   183 DLEAYGERLLHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAERKPLSEISRNFDLVLVNQHFTL 247
            |...:.||:.:......|.|...:..:.|.|.:..::  ::...|.:.::.....|.::.....|
  Rat   186 DRMNFLERMKNTGVYLISRMGVSFLVLPKYERIMQKY--NLLPAKSMYDLVHGSSLWMLCTDVAL 248

  Fly   248 GPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDRRKVLLE 312
            ..|||.:||::.|||: :......|..:|..::.||.|.|.:..|.|..|  |.||||....|..
  Rat   249 EFPRPTLPNVVYVGGI-LTKPASPLPEDLQRWVDGAQEHGFVLVSFGAGV--KYLSEDIANKLAG 310

  Fly   313 TFASLPQRIVWKFEDELLPGKPP-----NVFISKWFPQQAILAHPNVKLFITHGGLLSTIESIHH 372
            ....|||:::|:|.     |..|     |..:.:|.||..:|.|.|::.|::||||.|..|:::|
  Rat   311 ALGRLPQKVIWRFS-----GTKPKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNSIFETMYH 370

  Fly   373 GKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARYRD 437
            |.|::|:|...|.:..|..|:..|:|::|....:|..|....:::::.|.|:.:.|:..:..::|
  Rat   371 GVPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKLSEIHKD 435

  Fly   438 QPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALVILGIVTYLLVMTL 502
            ||..|:....:|.:|:|.|.||.|::.|...:.|.:|..||:....|:||:.:..||:|:.....
  Rat   436 QPGHPVNRTTYWIDYILRHDGAHHLRSAVHQISFCQYFLLDIAFVLLLGAVALYFIVSYVTKFIY 500

  Fly   503 RKCLFLIKR 511
            ||...|..|
  Rat   501 RKVKSLCSR 509

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	124/478 (26%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	131/500 (26%)
Ugt8	NP_062149.1	egt	8..490	CDD:223071	132/506 (26%)
Ugt8	NP_062149.1	UDPGT	21..502	CDD:278624	132/505 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344183
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8933
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.740