DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35D1 and Ugt303B1

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_651153.1	Gene:	Ugt303B1 / 42775	FlyBaseID:	FBgn0039086	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	521	Identity:	173/521 - (33%)
Similarity:	285/521 - (54%)	Gaps:	40/521 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLVCLLPGY--SEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRNIHDIP 68
            |.:|||..:  ::.|.||.:||....|.:|...|.:::||:.||.:|.::|.........:..|.
  Fly    10 LSLCLLLQHDRAQAANILGIFPYRHISPFFVMQPLVRTLATRGHNVTLITPIGMPNDIEGVRHIR 74

  Fly    69 VPEVFENFNEVL---RIASTPRSTWQSSDFINEYVLNLTKTVLNNEGVRRDILGPQKPHFDLVIM 130
            |.::.|...|:|   ::.....:.|..|....:.:.|.:..:|::.||:| :|..:...|||:||
  Fly    75 VAQLNERIKEMLESDQVLDFMINKWTESALTAKALFNASNDILSDPGVQR-MLHDKSESFDLIIM 138

  Fly   131 DLWRMDVLSGLAAYFDAPIIGMASYGTDWKIDELMGNVSPISYLQSPSSRF-YDLEAYGERLLHL 194
            :...:|.|.||..:::|.::|::|...:|...||.||.:|..|  .|.|.. :.||.      .|
  Fly   139 EPSSLDALYGLVEFYNATLMGLSSIRINWHTYELAGNPAPSIY--EPISPVGFSLET------SL 195

  Fly   195 MERTFSYMNYKWRHVRKQET------------LYSQFFPSVAERKPLSEISRNFDLVLVNQHFTL 247
            ..|.     |.|.|:.:::.            |:.:||...|::  ::|:...|.|:|:|.|:::
  Fly   196 FSRV-----YNWIHIMEEKLVNYLILRPAQLHLFQKFFGYSAQK--MNELRSRFSLMLINSHYSM 253

  Fly   248 GPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDRRKVLLE 312
            |..|...||:|:|||||:....|....||..|:..| :.||||||:|.::..|.|.|:.:::||:
  Fly   254 GKVRANAPNIIEVGGLHLSEPPEPSDEELQKFLDKA-DHGVIYFSMGNDILIKFLPENIQELLLQ 317

  Fly   313 TFASLPQRIVWKFEDELLPGKPPNVFISKWFPQQAILAHPNVKLFITHGGLLSTIESIHHGKPML 377
            |||:|.:.|:||.|...:|.|..||::.:..||:.||.||||:||||:|||||.||::..|.|||
  Fly   318 TFATLNESIIWKSELLYMPDKSDNVYVVEQAPQRHILNHPNVRLFITNGGLLSVIEAVDSGVPML 382

  Fly   378 GLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARYRDQPMKP 442
            |||..||||.||..|:..|:..|::|..:..:....||..:|.|.|:...|:..:..::|:||.|
  Fly   383 GLPMFFDQFGNMRWVQLSGMAEVMDINSLNKDTLTETIKHMLANNSYYLKAKEISQFFKDRPMSP 447

  Fly   443 METAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTF-----LVGALVILGIVTYLLVMTL 502
            ::||:|||||.|.::....|::..:::..:.|:.:|....|     ||.|.:|..:.|..|...:
  Fly   448 LDTAVWWTEYALRNRNITRMRLNLEEIPLIEYYRIDSILAFSLRFGLVAASLIFLVYTLFLKYRI 512

  Fly   503 R 503
            |
  Fly   513 R 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	162/473 (34%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	164/495 (33%)
Ugt303B1	NP_651153.1	egt	21..462	CDD:223071	158/457 (35%)
Ugt303B1	NP_651153.1	UDPGT	41..511	CDD:278624	161/486 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445602
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	11	10.800