DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35D1 and Ugt37A2

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_650228.1	Gene:	Ugt37A2 / 41573	FlyBaseID:	FBgn0038082	Length:	530	Species:	Drosophila melanogaster

Alignment Length:	527	Identity:	165/527 - (31%)
Similarity:	266/527 - (50%)	Gaps:	35/527 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IFLL----VCLLPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRNI 64
            |:||    :|:|.| ..||.||.||...|.||....:...|.||..||.:|.::........:||
  Fly     7 IYLLLATAICVLGG-CHGANILGVFTSLSPSHLIIQMSTAKVLAERGHNVTVITVLKPVVNHKNI 70

  Fly    65 HDIPVPEVFENFNEVLRIASTPRSTWQSSDFIN--------EYVLNLTKTVLNNEGVRRDILGPQ 121
            ..|.||...|...::.........|..|:..::        |::.:.....|.::.| ||:...:
  Fly    71 TVIMVPLTKEESQQMSDTIGAMSKTDNSNMILSMLRMMGQMEFMFDKMAGALKDDRV-RDLYLNR 134

  Fly   122 KPHFDLVI----MDLWRMDVLSGLAAYFDAPIIGMASYGTDWKIDELMGNVSPISYLQSPSSRFY 182
            ...||||:    |:::::    |.|....||:|.:|:...:..::.|:||...|:|:.|.|.
  Fly   135 DNKFDLVLSGYFMNVYQL----GFAKKVKAPVIVVATMPPNQLLNPLIGNPLEIAYVPSISD--- 192

  Fly   183 DLE-----AYGERLLHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAERKPLSEISRNFDLVLVN 242
            .:|     ::.:||.. ...:|.:..:.:...|:.:.||.:.|.........||:.:|..|:...
  Fly   193 SVEKGKGMSFRQRLAG-YSSSFFFGIFDFVTQRRSKRLYKELFGDDPNMPEYSELVKNTSLIFFA 256

  Fly   243 QHF-TLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDR 306
            .|. :.||.||.||..|::||:.|..:.:.|...:..|: |....|.|..|||:|||...::.|.
  Fly   257 SHAPSEGPIRPNVPAAIEIGGIQVKDTPDPLPQNMAEFL-GNATDGAILLSLGSNVKGSHINPDT 320

  Fly   307 RKVLLETFASLPQRIVWKFED-ELLPGKPPNVFISKWFPQQAILAHPNVKLFITHGGLLSTIESI 370
            ...:....:.|.||::||:|| |..|||..|:|.|||.||..||||||:||||.|.|.....|:.
  Fly   321 VVKMFNVLSKLKQRVIWKWEDLEKTPGKSDNIFYSKWLPQDDILAHPNIKLFINHAGKGGITEAQ 385

  Fly   371 HHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARY 435
            :||||||.||...||..|.|.:.:.|.||..::..:..:.|:..|:.:|:|..:.:.....::.|
  Fly   386 YHGKPMLSLPVFGDQPGNADVMVKQGFGLTQSLLSLEEQPFKEAILEILSNPQYFDKVASFSSLY 450

  Fly   436 RDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALVILGIVTYLLVM 500
            ||:||...|:.|:|||||:.|.||||:|.....:.|:..:::|::....| .||||.::..||:.
  Fly   451 RDRPMSARESVIYWTEYVIRHHGAAHLQSPLVHMSFIAANNIDIYALIAV-VLVILVLLLKLLLQ 514

  Fly   501 TLRKCLF 507
            .:.:.:|
  Fly   515 FIYRKIF 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	153/480 (32%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	152/497 (31%)
Ugt37A2	NP_650228.1	egt	8..490	CDD:223071	155/492 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445722
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D53444at6656
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14789
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	8	7.950