DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35D1 and Ugt35A1

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_524314.2	Gene:	Ugt35A1 / 41334	FlyBaseID:	FBgn0026315	Length:	537	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	230/519 - (44%)
Similarity:	331/519 - (63%)	Gaps:	31/519 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 EGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPY--PQREP-FRNIHDIPVPEVFENFN 77
            :.:|||||||.|..|.|.||..::|.||..||.:|.::.:  .:.|| ||.|....:.|:...|.
  Fly    30 QSSRILAVFPFPGRSQYIFAEQFMKELAHRGHNVTVINTFGSDKNEPNFRVIGAKKIHEIMAAFG 94

  Fly    78 EVLRIASTPRSTWQSSDFINEYVLNLTKTVLNNEGVRRDILGPQKPHFDLVIMDLWRMDVLSGLA 142
            ..  ..:...|.||......:::..||.::|::..| :|:|...: .||||||:..:.:.|.||.
  Fly    95 NA--DYTQTASQWQMLTMTTQFLNLLTTSILDDAAV-KDLLNSGE-KFDLVIMEAVQTEALFGLI 155

  Fly   143 AYFDAPIIGMASYGTDWKIDELMGNVSPISYLQSP---SSRFYDLEAYGERLLHLMERTFSYMNY 204
            .:|.|..||::|||||..|||||||:||:||  :|   |||...:: :.:|::::.|.:..:::.
  Fly   156 QHFGAETIGISSYGTDTHIDELMGNISPLSY--NPLLLSSRTEQMD-FKDRVMNVFEASVMWLHK 217

  Fly   205 KWRHVRKQETLYSQFFPSVAERKPLSEISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVD--H 267
            :..|:..|..||:::||:.  ||.|.|:..:|.|:|:.|||:|..||||:||||:|||||:.  .
  Fly   218 RIVHLPSQRDLYAKYFPTA--RKSLDEVLDSFALMLLGQHFSLSYPRPYLPNMIEVGGLHLQQKR 280

  Fly   268 STEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPG 332
            ..:.|:.||..|:: ..|.||||||:|:|:|||.|....||:|::||||:|||::|||||:.||.
  Fly   281 KVQPLAKELSEFVE-QSEKGVIYFSMGSNIKSKDLPPSTRKMLMQTFASVPQRVLWKFEDDQLPE 344

  Fly   333 KPPNVFISKWFPQQAILAHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGL 397
            ||.||||||||||..|||||||||||||||||||||||:.|||:||||..:||..|:...:|||.
  Fly   345 KPDNVFISKWFPQPDILAHPNVKLFITHGGLLSTIESIYFGKPILGLPIFYDQHLNVQRAKQVGY 409

  Fly   398 GLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHM 462
            ||..:|..:.:.|....|..||:|.|:...|:..:..:|||....:|.|||||||||.||||.|:
  Fly   410 GLSADIWSVNATELTPLIQELLSNPSYAAAAQTKSKLFRDQKETALERAIWWTEYVLRHKGAKHL 474

  Fly   463 QVAGKDLGFVRYHSLDVFGTFLVGALVILGIVTYLLVMTLRKCL---FL-----IKRGKCEAIK 518
            :.|.:||.|:::|.||.:     |.|:.:..|:.|:|:.|.|||   |:     |::.:.||.|
  Fly   475 RCASRDLDFIQFHGLDTW-----GLLIAITFVSLLIVVILIKCLQRVFVSLISKIRKNRAEASK 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	208/453 (46%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	219/496 (44%)
Ugt35A1	NP_524314.2	egt	19..474	CDD:223071	208/453 (46%)
Ugt35A1	NP_524314.2	UDPGT	55..526	CDD:278624	214/485 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45445577
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	1	1.000	-	-		H55988
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D45181at50557
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	12	11.800