DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and Ugt1a3

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_958827.1	Gene:	Ugt1a3 / 396551	RGDID:	1549728	Length:	531	Species:	Rattus norvegicus

Alignment Length:	541	Identity:	139/541 - (25%)
Similarity:	255/541 - (47%)	Gaps:	77/541 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IFLLVCLLPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSP----YPQREPFRNI 64
            :.||:|.|| ::||.::| |||: ..||:......::.|.:.||:...::|    :.:.|.|..:
  Rat    13 LLLLLCALP-WAEGGKVL-VFPM-EGSHWLSMRDVVRELHARGHQAVVLAPEVTVHIKEEDFFTL 74

  Fly    65 HDIPVPEVFENFNEVL-------------------RIASTPRSTWQSSDFINEYVLNLTKTVLNN 110
            ...|||...|.:...|                   |:|:.        :.::.:.:...:.:|:|
  Rat    75 QTYPVPYTKEEYRHHLLGHLQNFFETEFSLKLVLQRMAAV--------NNVSTFYVRSCRGLLHN 131

  Fly   111 EGVRRDILGPQKPHFDLVIMDLWRMDVLSGLAAYFDAPIIGMASYGTDWKIDELMGNVSPISYLQ 175
            ..:.:.:   ....||:|:.|.: ....:.||.|...|.:....              |.:..|:
  Rat   132 TALIQSL---NSSSFDVVLTDPF-FPCGAVLAMYLRVPAVFFLQ--------------SMLCELE 178

  Fly   176 SPSSRFYDLEAYGERLLHLMERTFSYMNYKWRHVRKQETLY---------------SQFFPSVAE 225
            ..::...:..:|..|||.|.....|:::      |.:..||               ::....:.:
  Rat   179 FEATNSPNPSSYIPRLLTLNSDHMSFLD------RVKNMLYPVPWMYLCHVNYGSLARLASDLLQ 237

  Fly   226 RK-PLSEISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVI 289
            |: .:.||.|:..:.|:.:.|....|||::|||:.:||::. .:.:.||.|.:.::..:||.|::
  Rat   238 REVSVVEILRHASVWLLRKDFVFYYPRPFMPNMVFIGGINC-ANRKPLSQEFEAYVNASGEHGIV 301

  Fly   290 YFSLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPPNVFISKWFPQQAILAHPNV 354
            .||||:.|  ..:.|.:...:.|....:||.::|::..........|..:.||.||..:|.||..
  Rat   302 VFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKA 364

  Fly   355 KLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLL 419
            :.||||.|.....|.|.:|.||:.:|...||..|...:...|.|:.||:.:||:::..:.:..::
  Rat   365 RAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVI 429

  Fly   420 TNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFL 484
            .|||::|.....::.::|:|::|::.|::|.|||:.||||.|::.|..||.:.:||||||.|..|
  Rat   430 NNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLL 494

  Fly   485 VGALVILGIVTYLLVMTLRKC 505
            ...|.::.||........|||
  Rat   495 AIVLTVVFIVYKSCAYGCRKC 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	121/496 (24%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	128/515 (25%)
Ugt1a3	NP_958827.1	UDPGT	26..522	CDD:278624	132/527 (25%)
Ugt1a3	NP_958827.1	egt	<228..505	CDD:223071	88/279 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8933
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860