DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and Ugt1a6b

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_958812.3	Gene:	Ugt1a6b / 394435	MGIID:	3580629	Length:	531	Species:	Mus musculus

Alignment Length:	551	Identity:	148/551 - (26%)
Similarity:	255/551 - (46%)	Gaps:	88/551 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVCLLPGYSE---------------GARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSP-- 54
            :.||||....               |.::|.| | ...||:......::.|:..||:|..:.|
Mouse     1 MACLLPAAQTLPAGFLFLVLWASVLGDKLLVV-P-QDGSHWLSMKEIVEHLSERGHDIVVLVPEV 63

  Fly    55 --------YPQREPFRNIHDIPVPEVFENFNEVLRIASTPRSTWQSSDFI---------NEY--- 99
                    |.:|:.|      .||...|......|       |:..:.|:         .||
Mouse    64 NLLLGESKYYRRKIF------SVPYSLEELQTRFR-------TFGRNQFVPGAPLMGPLREYRNS 115

  Fly   100 VLNLTKTVLNNEGVRRD-----ILGPQKPHFDLVIMD-LWRMDVLSGLAAYFDAPIIGMASYGTD 158
            :|.|.....|.:.:.:|     .|...|  ||.:..| .....|:  ||.|.:.|.:.:.. |..
Mouse   116 MLTLEMFFSNCQSLLKDSATLSFLRENK--FDALFTDPAMPCGVI--LAEYLNLPSVYLFR-GFP 175

  Fly   159 WKIDELMG-NVSPISYLQSPSSRFYDLEAYGERL----LHLMERTFSYMNYKWRHVRKQETLYSQ 218
            ..::.::| :.||:||:....::|.|...:.:||    ::::|   :|:.|         .|||:
Mouse   176 CSLEHMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIVNILE---NYLYY---------CLYSK 228

  Fly   219 FFPSVAE--RKPLS--EISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHF 279
            :...|.:  ::.:|  .:.:| .|.|:...|....|||.:||||.:||::.....: |:.|.:.:
Mouse   229 YEIIVTDLLKRDVSLPSLHQN-SLWLLRYDFVFEYPRPIMPNMIFIGGINCKKKGK-LTQEFEAY 291

  Fly   280 IQGAGESGVIYFSLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPPNVFISKWFP 344
            :..:||.|::.||||:.|  ..:.|.:...:.|....:||.::|::..........|..:.||.|
Mouse   292 VNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLP 354

  Fly   345 QQAILAHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSE 409
            |..:|.||..:.||||.|.....|.|.:|.||:.:|...||..|...:...|.|:.||:.:||::
Mouse   355 QNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTAD 419

  Fly   410 EFRSTIIRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRY 474
            :..:.:..::.|||::|.....::.::|:|::|::.|::|.|||:.||||.|::.|..||.:.:|
Mouse   420 DLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQY 484

  Fly   475 HSLDVFGTFLVGALVILGIVTYLLVMTLRKC 505
            |||||.|..|...|.::.||........|||
Mouse   485 HSLDVIGFLLAIVLTVVFIVFKCCAYGCRKC 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	130/506 (26%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	140/513 (27%)
Ugt1a6b	NP_958812.3	egt	15..503	CDD:223071	139/523 (27%)
Ugt1a6b	NP_958812.3	UDPGT	27..522	CDD:278624	143/525 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840672
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690