DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and Ugt1a5

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_964005.2	Gene:	Ugt1a5 / 394433	MGIID:	3032634	Length:	529	Species:	Mus musculus

Alignment Length:	523	Identity:	148/523 - (28%)
Similarity:	256/523 - (48%)	Gaps:	46/523 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLVCLLPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYP----QREPFRNIHD 66
            ||:|.|| ::||.::| |||: ..||:......::.|.:.||:...::|..    :.|.|.....
Mouse    14 LLLCALP-WTEGEKVL-VFPV-GGSHWLSMRDVVRELHAQGHQTVVLAPEVNMRIKEEDFFTFKV 75

  Fly    67 IPVP-------EVFENFNEVLRIASTPRSTWQSSDFINEYVLNLTKT---VLNNEGVRRDILGPQ 121
            ..||       |:.||........:..:..:::|:.:......|.||   :|:||.:...:   .
Mouse    76 YAVPYTRQELEEMMENLKVFFDTGNYMKKIFKTSEALRNMSTVLLKTCTNILHNESLLHHL---N 137

  Fly   122 KPHFDLVIMD-LWRMDVLSGLAAYFDAPIIGMASY---GTDWKIDELMGNVSPISYLQSPSSRFY 182
            ...||:|..| ::....|  ||.|...|.:....|   |.:::..:.   .||.||:.:..:|..
Mouse   138 SSSFDVVFTDPVFPCGAL--LAKYLGIPAVFFLRYIPCGIEYEATQC---PSPSSYIPNLFTRLS 197

  Fly   183 D----LEAYGERLLHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAERKPLS-EISRNFDLVLVN 242
            |    |:.....|.||:.:...::     .:...|:|.|:.|    :|:..| |:.....:.|..
Mouse   198 DHMDFLQRVQNMLYHLVLKYICHL-----LITPYESLASELF----QREVSSVELFSYASVWLFR 253

  Fly   243 QHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDRR 307
            ..|.|..|||.:|||:.:||::. .:.:.||.|.:.::..:||.|::.||||:.|  ..:.|.:.
Mouse   254 GDFVLDYPRPIMPNMVFIGGINC-VTKKPLSQEFEAYVNASGEHGIVVFSLGSMV--SEIPEKKA 315

  Fly   308 KVLLETFASLPQRIVWKFEDELLPGKPPNVFISKWFPQQAILAHPNVKLFITHGGLLSTIESIHH 372
            ..:.|....:||.::|::..........|..:.||.||..:|.||..:.||||.|.....|.|.:
Mouse   316 MEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICN 380

  Fly   373 GKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARYRD 437
            |.||:.:|...||..|...:...|.|:.||:.:||:::..:.:..::.|||::|.....::.::|
Mouse   381 GVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLSSLHKD 445

  Fly   438 QPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALVILGIVTYLLVMTL 502
            :|::|::.|::|.|||:.||||.|::.|..||.:.:||||||.|..|...|.::.||........
Mouse   446 RPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAYGC 510

  Fly   503 RKC 505
            |||
Mouse   511 RKC 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	130/478 (27%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	137/499 (27%)
Ugt1a5	NP_964005.2	UDPGT	26..520	CDD:278624	141/510 (28%)
Ugt1a5	NP_964005.2	egt	<257..501	CDD:223071	82/246 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840621
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690