DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35D1 and Ugt1a7c

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_964004.1	Gene:	Ugt1a7c / 394432	MGIID:	3032636	Length:	531	Species:	Mus musculus

Alignment Length:	558	Identity:	149/558 - (26%)
Similarity:	248/558 - (44%)	Gaps:	112/558 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLVCLL--PGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRNIHDIP 68
            |.||||  .|.::..|:|.| |: ..||:|.....::.|...|||:..|
Mouse    12 LCVCLLLASGLAQAGRLLVV-PM-DGSHWFTMQTVVEKLLHKGHEVVVV---------------- 58

  Fly    69 VPEVFENFNEVLRIASTPRSTWQSSDFIN----EYVLNLTKTVLNNE---------------GVR 114
            ||||                :||.:..:|    .|.::.|:..||.|               |:.
Mouse    59 VPEV----------------SWQLTKPLNFVVKTYAVSHTQEDLNREFKIFIDAQWKSQQEGGIL 107

  Fly   115 RDILGPQK-------------------------PHFDLVIMDLWRMDVLSGLAAYFDAPIIGMAS 154
            ..:..|.|                         ..||.|.:|.:.:..|: :|.||..|.:..:.
Mouse   108 PLLDSPAKGFFELLFSHCRSLFNDKKLVEYLKQTSFDAVFLDPFDVCGLT-VAKYFSLPSVVFSR 171

  Fly   155 YGTDWKIDELMGNVSPISYLQSPSSRFYDLEAYGER----LLHLMERTFSYMNYKWRHVRKQETL 215
            ......:::.....||.||:.....:|.|...:.||    |.::.||.|.:
Mouse   172 GIFCHYLEDAAQCPSPPSYIPRMLLKFTDTMTFKERTRNLLAYMGERAFCH-------------- 222

  Fly   216 YSQFFPSVAE------RKP--LSEISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEAL 272
              :||.|.|:      :.|  ::::.....:.|:...|.|..|||.:||:|.:||::. |..:.|
Mouse   223 --KFFKSAADIASEVLQTPVTMTDLFSPVSIWLLRTDFVLEFPRPVMPNVIYIGGINC-HQGKPL 284

  Fly   273 SAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPPNV 337
            |.|.:.::..:||.|::.||||:.|  ..:.|.:...:.|....:||.::|::..........|.
Mouse   285 SKEFEAYVNASGEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNT 347

  Fly   338 FISKWFPQQAILAHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLN 402
            .:.||.||..:|.||..:.||||.|.....|.|.:|.||:.:|...||..|...:...|.|:.||
Mouse   348 ILVKWLPQNDLLGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLN 412

  Fly   403 IKQMTSEEFRSTIIRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGK 467
            :.:||:::..:.:..::.|||::|.....::.::|:|::|::.|::|.|||:.||||.|::.|..
Mouse   413 VLEMTADDLENALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAH 477

  Fly   468 DLGFVRYHSLDVFGTFLVGALVILGIVTYLLVMTLRKC 505
            ||.:.:||||||.|..|...|.::.||........|||
Mouse   478 DLTWYQYHSLDVIGFLLAIVLTVVFIVFKCCAYGCRKC 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	131/513 (26%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	139/532 (26%)
Ugt1a7c	NP_964004.1	UDPGT	26..522	CDD:278624	143/544 (26%)
Ugt1a7c	NP_964004.1	egt	<225..503	CDD:223071	89/280 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840670
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690