DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35D1 and Ugt49B1

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_611563.1	Gene:	Ugt49B1 / 37420	FlyBaseID:	FBgn0027073	Length:	532	Species:	Drosophila melanogaster

Alignment Length:	518	Identity:	173/518 - (33%)
Similarity:	272/518 - (52%)	Gaps:	35/518 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IFLLVCLLPGYSE---GARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPY--PQREPFRN 63
            ||||..:.....|   |:||||.|..|..||:......::.|...|||:|.::|:  .:.:...|
  Fly     9 IFLLSLVALQQLELGTGSRILAAFFFPGKSHFMMTNAIIRELVKQGHEVTFITPFSLAKEKLGSN 73

  Fly    64 IHDIPV------PEVFE--NFNEVLRIASTPRSTWQSSDFINEYVLNLTKTVLNNEGVRRDILGP 120
            ..:|.:      ||:.|  |.|.||.:...|  |:.....:|...::.|...|....::..|...
  Fly    74 YKEIVIPQYDFWPEIKEMTNKNTVLEMTDLP--TFAFLRMVNVMGIHTTDFALEQPEIQAVINEK 136

  Fly   121 QK-PHFDLVIMDLWRMDVLSGLAAYFDAPIIGMASYGTDWKIDELMGNVSPISYLQSPSSRFYDL 184
            .| ..:||::.:.:..:....|...:..|.|.::::|....:.:|.|.|||.||:......:.|.
  Fly   137 NKIGKYDLLLAEQFFNEGALILGHLYQIPTITISTFGNANHLSQLFGVVSPWSYVPHAYMPYTDR 201

  Fly   185 EAYGERLLHL-------MERTFSYMNYKWRHVRKQETLYSQFFPSVAERKP-LSEISRNFDLVLV 241
            ....||:.::       :.|.|||       ...|:.:..:.|..:.:|.| :.|:.||...:|:
  Fly   202 MTLWERIGNVAMSAAEDLVREFSY-------YPGQDAVLKKHFSKLLDRVPTIKELERNISAILL 259

  Fly   242 NQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDR 306
            |.:..|...||...|||.|||||: ...:||...|..|:.|| ..|.||||||:.|:|..|..::
  Fly   260 NSYMPLASSRPMAYNMIPVGGLHI-QPPKALPEHLQKFLDGA-THGAIYFSLGSQVRSADLPPEK 322

  Fly   307 RKVLLETFASLPQRIVWKFEDELLPGKPPNVFISKWFPQQAILAHPNVKLFITHGGLLSTIESIH 371
            .||.||.|.||.||::||||||.||..|.||.:..|.||..||||||||:||.||||..|.|:::
  Fly   323 LKVFLEVFGSLKQRVLWKFEDESLPNLPANVKVQSWLPQGDILAHPNVKVFIAHGGLFGTQEAVY 387

  Fly   372 HGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARYR 436
            :|.|:||:|...||.:|::..:.....|.|:.:::|.||.|..::.|:.|..:....:..:..:|
  Fly   388 NGVPILGMPVYCDQHQNINQGKSAEYALGLDYRKVTVEELRGLLMELIENPKYRNNIKKASRIFR 452

  Fly   437 DQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALVILGIVTYLLV 499
            |:|:..|:|||:|..||:.|:||.|:..||..|.:.:::.||:.|..|  |:::|.||..:|:
  Fly   453 DRPLGAMDTAIYWINYVIEHRGAPHLVAAGVHLPWYQFYLLDIVGLGL--AVILLPIVVLILI 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	160/479 (33%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	161/489 (33%)
Ugt49B1	NP_611563.1	egt	7..513	CDD:223071	172/516 (33%)
Ugt49B1	NP_611563.1	UDPGT	38..515	CDD:278624	161/489 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45454706
Domainoid	1	1.000	76	1.000	Domainoid score	I3136
eggNOG	1	0.900	-	-		E33208_3BDT1
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	89	1.000	Inparanoid score	I2281
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	1	1.100	-	-	P	PTHR48043
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
	10	9.790