DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and Ugt2b37

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001007265.4	Gene:	Ugt2b37 / 29623	RGDID:	3937	Length:	530	Species:	Rattus norvegicus

Alignment Length:	551	Identity:	149/551 - (27%)
Similarity:	264/551 - (47%)	Gaps:	61/551 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IFLLVCLLPGY----SEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPY------PQR 58
            ||.|:.|...:    ::..::| |:|: ..||:......|..|...|||:|.:.|.      |::
  Rat     6 IFALLLLQISFCLRSAKCGKVL-VWPM-EFSHWMNIKTILDELVQRGHEVTVLKPSAYYVLDPKK 68

  Fly    59 EPFRNIHDIPV---PEVFENFNEVLRIAST---PRSTWQS--------SDFINEYVLNLTKTVLN 109
            .|.......|.   .:..|.:...|..|.|   .|.|..|        .|..::|.|::.|..::
  Rat    69 SPDLKFETFPTSVSKDELEKYFIKLVDAWTYELQRDTCLSFSPLLQNMMDEFSDYYLSVCKDAVS 133

  Fly   110 NEGVRRDILGPQKPHFDLVIMD-------LWRMDVLSGLAAYFDAPIIGMASYGTDWKIDELMGN 167
            |:.:...:   |:..||:::.|       |        :|.....|.:.........||::..|.
  Rat   134 NKQLMAKL---QESKFDVLLSDPVAACGEL--------IAEVLHIPFLYSLRASPGHKIEKSSGR 187

  Fly   168 -VSPISYLQSPSSRFYDLEAYGERLLHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAER-KPLS 230
             :.|.||:....|.......:.:|:.:::  ...|.:: |.|:...:. :..|:..:..| ..|:
  Rat   188 FILPPSYVPVILSGLGGQMTFIDRVKNMI--CMLYFDF-WFHMFNAKN-WDPFYTEILGRPTTLA 248

  Fly   231 EISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGT 295
            |.....::.|:..::.|..|.|.:||:..:|||.. ...:.|..:::.|:|.:||.||:.||||:
  Rat   249 ETMGKAEMWLIRSYWDLEFPHPTLPNVDYIGGLQC-KPAKPLPKDIEDFVQSSGEHGVVVFSLGS 312

  Fly   296 NVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPPNVFISKWFPQQAILAHPNVKLFITH 360
            .|  .|::|::...:....|.:||:::|||:.::.....||..:.||.||..:|.||..|.|:||
  Rat   313 MV--SSMTEEKANAVAWALAQIPQKVLWKFDGKIPATLGPNTRVYKWLPQNDLLGHPKTKAFVTH 375

  Fly   361 GGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFE 425
            ||.....|:|:||.||:|:|...:|..|:.|:...|..:.|||:.|:..:..:.:..::.|..::
  Rat   376 GGANGVYEAIYHGIPMIGIPMFGEQHDNIAHMVAKGAAVTLNIRTMSKSDLFNALKEVINNPFYK 440

  Fly   426 ETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALVI 490
            :.|...:..:.||||||::.||:|.|||:.||.|.|::..|.:|.:.:||||||.| ||:..|.:
  Rat   441 KNAMWLSTIHHDQPMKPLDKAIFWIEYVMRHKRAKHLRPLGHNLPWYQYHSLDVIG-FLLACLAV 504

  Fly   491 LGIVTYLLVMTLRKCLFLIKRGKCEAIKKIQ 521
            :..:..       ||...|.|...:..||::
  Rat   505 IAALAV-------KCFLFIYRFFAKKQKKMK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	130/490 (27%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	139/509 (27%)
Ugt2b37	NP_001007265.4	UDPGT	24..527	CDD:278624	144/530 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8933
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760