DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35D1 and Ugt2b7

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_775445.2	Gene:	Ugt2b7 / 286989	RGDID:	708417	Length:	529	Species:	Rattus norvegicus

Alignment Length:	530	Identity:	144/530 - (27%)
Similarity:	250/530 - (47%)	Gaps:	81/530 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VFPLPSSSHYFFALPYLKSLASLGHEITSVSPY------PQREPFRNIHDIPVPEVFENFNEVLR 81
            |:|| ..||:......|..|...|||:|.:.|.      |::.........|..   .|.:||.:
  Rat    28 VWPL-EYSHWMNLKIILDELVQRGHEVTVLRPSSSVFLDPKKASGLVYETFPTT---SNNDEVEK 88

  Fly    82 IASTPRSTW---------------------QSSDFINEYVLNLTKTVLNNEGVRRDILGPQKPHF 125
            ..:...:||                     |.||.    .|.|.:.|::|:.:...:   ::..|
  Rat    89 FFTQWVNTWTYDVPKYTCLRYYPSLNKMFGQFSDL----WLQLCREVVSNKHLMAKL---KESQF 146

  Fly   126 DLVIMDLWRMDVLSG-----LAAYFDAPIIGMASYGTDWKIDEL-MGNVSPISY----LQSPSSR 180
            |:|:.|      ..|     :|.....|.:....:|..:.|::. .|...|.||    |...|.:
  Rat   147 DVVLSD------AVGPCGELIAEILQLPFVYSLRFGIGYGIEKYSAGQPFPPSYVPIILSGLSGQ 205

  Fly   181 FYDLEAYGERLLHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAER-KPLSEISRNFDLVLVNQH 244
            ...:|.. |.:|.|:...|.:.::..:.       :..||..:..| ..:.:..:..::.|:..:
  Rat   206 MTFMERV-ENMLCLLYFDFWFESFPAKD-------WDPFFSEILGRPTTMVDTMKKAEIWLIRSY 262

  Fly   245 FTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDRRKV 309
            :.|..|||.:||:..|||||. ...:.|..|::.|.|.:||.||:.||||:.:  ::::::|...
  Rat   263 WDLEFPRPSLPNIEFVGGLHC-QPAKPLPKEMEDFAQSSGEHGVVVFSLGSMI--RNITQERANT 324

  Fly   310 LLETFASLPQRIVWKFEDELLPGKP----PNVFISKWFPQQAILAHPNVKLFITHGGLLSTIESI 370
            :....|.:||::.|:||.:    ||    ||..:.||.||..:|.||..|.|:||||.....|||
  Rat   325 IASALAQIPQKVFWRFEGK----KPDTLGPNTRVFKWIPQNDLLGHPKTKAFVTHGGANGIYESI 385

  Fly   371 HHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARY 435
            |||.||:|:|...:|..|:.|:...|..:.|:...|:|.:..:.:..::...|:::.....:|.:
  Rat   386 HHGIPMVGIPLFAEQRDNVAHMVAKGAAVSLDFHTMSSSDLLNALKAVINKPSYKKKVMWLSAIH 450

  Fly   436 RDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALVILGIVTYLLVM 500
            .|||:||::.|::|.|:|:.||||.|::....:|.:.:||||||.|       .:|..|..::::
  Rat   451 HDQPLKPLDRAVFWIEFVMRHKGAKHLRPLAHNLAWYQYHSLDVIG-------FLLACVLAIVLL 508

  Fly   501 TLRKCLFLIK 510
            .::.||||.:
  Rat   509 AVKCCLFLYR 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	129/480 (27%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	141/523 (27%)
Ugt2b7	NP_775445.2	UDPGT	24..527	CDD:278624	144/530 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8933
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.860