DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35D1 and Ugt2b17

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_775417.1	Gene:	Ugt2b17 / 286954	RGDID:	708541	Length:	529	Species:	Rattus norvegicus

Alignment Length:	544	Identity:	160/544 - (29%)
Similarity:	277/544 - (50%)	Gaps:	57/544 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IFLLVCLLPGYSEGA--RILAVFPLPSSSHYFFALPYLKSLASLGHEIT------SVSPYPQREP 60
            :|||:.|:..:..||  ::| |:| ...||:......|..||..|||:|      |:...|.:|.
  Rat     8 VFLLIQLICYFRPGACGKVL-VWP-TEYSHWINIKIILNELAQRGHEVTVLVSSASILIEPTKES 70

  Fly    61 FRN--IHDIPVPEVFENFNEVLRIASTPR-----STW----QSSDFINEY---VLNLTKTVLNNE 111
            ..|  |:.:|:.:....::....|....|     |.|    :.....|||   |.||.|.::.|:
  Rat    71 SINFEIYSVPLSKSDLEYSFAKWIDEWTRDFETLSIWTYYSKMQKVFNEYSDVVENLCKALIWNK 135

  Fly   112 GVRRDILGPQKPHFDLVIMDLWRMDVLSG-----LAAYFDAPIIGMASYGTDWKIDELMGNVS-P 170
            .:.:.:.|.|   ||:::.|      ..|     ||.....|::....:...::.::..|.:. |
  Rat   136 SLMKKLQGSQ---FDVILAD------AVGPCGELLAELLKTPLVYSLRFCPGYRCEKFSGGLPLP 191

  Fly   171 ISYLQSPSSRFYDLEAYGERLLHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAER-KPLSEISR 234
            .||:....|...|...:.||:.::::  ..|.:: |....|::: :|||:..|..| ..|:|:..
  Rat   192 PSYVPVVLSELSDRMTFVERVKNMLQ--MLYFDF-WFQPFKEKS-WSQFYSDVLGRPTTLTEMMG 252

  Fly   235 NFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKS 299
            ..|:.|:...:.|..|.|::||...|||||. ...:.|..|::.|:|.:||.||:.||||:.|
  Rat   253 KADIWLIRTFWDLEFPHPFLPNFDFVGGLHC-KPAKPLPREMEEFVQSSGEHGVVVFSLGSMV-- 314

  Fly   300 KSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPP-----NVFISKWFPQQAILAHPNVKLFIT 359
            |:|:|::..|:....|.:||::||:|:     ||.|     |..:.||.||..:|.||..|.|:.
  Rat   315 KNLTEEKANVVASALAQIPQKVVWRFD-----GKKPDTLGSNTRLYKWIPQNDLLGHPKTKAFVA 374

  Fly   360 HGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSF 424
            |||.....|:|:||.|::|:|...||..|::|:...|..:.::...:::....:.:..::.:.|:
  Rat   375 HGGTNGIYEAIYHGIPIVGIPLFADQPDNINHMVAKGAAVRVDFSILSTTGLLTALKIVMNDPSY 439

  Fly   425 EETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALV 489
            :|.|...:..:.|||:||::.|::|.|||:.||||.|::....||.:.:||||||.|..|:..:.
  Rat   440 KENAMRLSRIHHDQPVKPLDRAVFWIEYVMRHKGAKHLRSTLHDLSWFQYHSLDVIGFLLLCVVG 504

  Fly   490 ILGIVTYLLVMTLRKCLFLIKRGK 513
            ::.|:|...:...||...:.|:.|
  Rat   505 VVFIITKFCLFCCRKTANMGKKKK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	143/491 (29%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	149/512 (29%)
Ugt2b17	NP_775417.1	UDPGT	24..527	CDD:278624	153/525 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8933
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760