DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and Ugt2b15

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_695226.3	Gene:	Ugt2b15 / 266685	RGDID:	628623	Length:	530	Species:	Rattus norvegicus

Alignment Length:	523	Identity:	143/523 - (27%)
Similarity:	257/523 - (49%)	Gaps:	57/523 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VFPLPSSSHYFFALPYLKSLASLGHEITSVSPY------PQREPFRNIHDIPV---PEVFENFNE 78
            |:|: ..||:......|..|...|||:|.:.|.      |::.|.......|.   .:..||:
  Rat    28 VWPM-EFSHWMNIKTILDELVQRGHEVTVLKPSAYYVLDPKKSPDLKFETFPTSVSKDELENY-- 89

  Fly    79 VLRIAST-----PRSTWQS--------SDFINEYVLNLTKTVLNNEGVRRDILGPQKPHFDLVIM 130
            .:::...     .|.|..|        .|..::|.|:|.|..::|:.:...:   |:..||:::.
  Rat    90 FIKLVDVWTYELQRDTCLSYSPLLQNMIDGFSDYYLSLCKDTVSNKQLMAKL---QESKFDVLLS 151

  Fly   131 DLWRMDVLSG--LAAYFDAPIIGMASYGTDWKIDELMGN-VSPISYLQSPSSRFYDLEAYGERLL 192
            |   .....|  :|.....|.:....:...:||::..|. :.|.||:....|.......:.:|:.
  Rat   152 D---PVAACGELIAEVLHIPFLYSLRFSPGYKIEKSSGRFILPPSYVPVILSGMGGPMTFIDRVK 213

  Fly   193 HLMERTFSYMNYKWRHV---RKQETLYSQFFPSVAERKPLSEISRNFDLVLVNQHFTLGPPRPYV 254
            :::  ...|.:: |.|:   :|.:..||:.   :.....|:|.....::.|:..::.|..|.|.:
  Rat   214 NMI--CTLYFDF-WFHMFNAKKWDPFYSEI---LGRPTTLAETMGKAEMWLIRSYWDLEFPHPTL 272

  Fly   255 PNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDRRKVLLETFASLPQ 319
            ||:..:|||.. ...:.|..:::.|:|.:||.||:.||||:.|  .|::|::...:....|.:||
  Rat   273 PNVDYIGGLQC-RPPKPLPKDMEDFVQSSGEHGVVVFSLGSMV--SSMTEEKANAIAWALAQIPQ 334

  Fly   320 RIVWKFEDELLPGKPPNVFISKWFPQQAILAHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFD 384
            :::|||:.:......||..:.||.||..:|.||..|.|:||||.....|:|:||.||:|:|...:
  Rat   335 KVLWKFDGKTPATLGPNTRVYKWLPQNDLLGHPKTKAFVTHGGANGVYEAIYHGIPMVGIPMFGE 399

  Fly   385 QFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARYRDQPMKPMETAIWW 449
            |..|:.|:...|..:.|||:.|:..:..:.:..::.|..:::.|...:..:.||||||::.|::|
  Rat   400 QHDNIAHMVAKGAAVTLNIRTMSKSDLFNALKEIINNPFYKKNAVWLSTIHHDQPMKPLDKAVFW 464

  Fly   450 TEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALVILGIVTYLLVMTLRKCLFL----IK 510
            .|:|:.||||.|::..|.:|.:.:||||||.|..|..:.||       .|:|::..||:    :|
  Rat   465 IEFVMRHKGAKHLRPLGHNLPWYQYHSLDVIGFLLTCSAVI-------AVLTVKSFLFIYRLFVK 522

  Fly   511 RGK 513
            :.|
  Rat   523 KEK 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	124/466 (27%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	139/512 (27%)
Ugt2b15	NP_695226.3	UDPGT	24..527	CDD:278624	143/523 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344071
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8933
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	11	10.690