DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35D1 and Ugt1a1

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_036815.1	Gene:	Ugt1a1 / 24861	RGDID:	3935	Length:	535	Species:	Rattus norvegicus

Alignment Length:	528	Identity:	145/528 - (27%)
Similarity:	249/528 - (47%)	Gaps:	53/528 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLVCLL-PGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSP----YPQREPFRNIH 65
            ||:|:| |..|...::| |.|: ..||:...|..::.|...|||:..::|    :.:...|..:.
  Rat    17 LLLCVLGPSASHAGKLL-VIPI-DGSHWLSMLGVIQQLQQKGHEVVVIAPEASIHIKEGSFYTMR 79

  Fly    66 DIPVPEVFENFNEVLRIASTPRSTWQSSDFINEYVLNLTKTVLNNEGVRRD-------------- 116
            ..|||  |:|.|.........||.:....|:    |.:.||.   ..|:||
  Rat    80 KYPVP--FQNENVTAAFVELGRSVFDQDPFL----LRVVKTY---NKVKRDSSMLLSGCSHLLHN 135

  Fly   117 ---ILGPQKPHFDLVIMDLWRMDVLSGLAAYFDAPIIGMASYGTDWKID-ELMGNVSPISY---- 173
               :...::.|||.::.|.: :...|.:|.|...|.:...: .....:| |.....:|:||
  Rat   136 AEFMASLEQSHFDALLTDPF-LPCGSIVAQYLSLPAVYFLN-ALPCSLDLEATQCPAPLSYVPKS 198

  Fly   174 LQSPSSRFYDLEAYGERLLHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAERK-PLSEISRNFD 237
            |.|.:.|...|:.....::.|.|      |:..|.|...   |......:.::: .:.::.....
  Rat   199 LSSNTDRMNFLQRVKNMIIALTE------NFLCRVVYSP---YGSLATEILQKEVTVKDLLSPAS 254

  Fly   238 LVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSL 302
            :.|:...|....|||.:|||:.:||::. ...:|||.|.:.::..:||.|::.||||:.|  ..:
  Rat   255 IWLMRNDFVKDYPRPIMPNMVFIGGINC-LQKKALSQEFEAYVNASGEHGIVVFSLGSMV--SEI 316

  Fly   303 SEDRRKVLLETFASLPQRIVWKFEDELLPGKPPNVFISKWFPQQAILAHPNVKLFITHGGLLSTI 367
            .|.:...:.|....:||.::|::..........|..:.||.||..:|.||..:.||||.|.....
  Rat   317 PEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDLLGHPKARAFITHSGSHGIY 381

  Fly   368 ESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITA 432
            |.|.:|.||:.:|...||..|...:...|.|:.||:.:||:::..:.:..::.|||::|.....:
  Rat   382 EGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLENALKTVINNKSYKENIMRLS 446

  Fly   433 ARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALVILGIVTYL 497
            :.::|:|::|::.|::|.|||:.||||.|::.|..||.:.:||||||.|..|...|.::.||...
  Rat   447 SLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAIVLTVVFIVYKS 511

  Fly   498 LVMTLRKC 505
            .....|||
  Rat   512 CAYGCRKC 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	127/483 (26%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	136/503 (27%)
Ugt1a1	NP_036815.1	UDPGT	30..526	CDD:278624	139/515 (27%)
Ugt1a1	NP_036815.1	egt	<263..509	CDD:223071	83/248 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	256	1.000	Domainoid score	I1959
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	275	1.000	Inparanoid score	I2882
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm8933
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.760