DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and Ugt2b5

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_033493.3	Gene:	Ugt2b5 / 22238	MGIID:	98900	Length:	530	Species:	Mus musculus

Alignment Length:	522	Identity:	144/522 - (27%)
Similarity:	254/522 - (48%)	Gaps:	64/522 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 VFPLPSSSHYFFALPYLKSLASLGHEITSVSPY------PQREPFRNIHDIPV---PEVFENFNE 78
            |:|: ..||:......|..|...|||:|.:.|.      |::.|.......|.   .:..|||
Mouse    28 VWPM-EFSHWMNIKIILDELVQRGHEVTVLRPSAYYVLDPKKSPGLKFETFPTSVSKDNLENF-- 89

  Fly    79 VLRIAST-----PRSTWQS--------SDFINEYVLNLTKTVLNNEGVRRDILGPQKPHFDLVIM 130
            .::....     ||.|..|        .|..::|.|:|.|.|::|:.:...:   |:..||:::.
Mouse    90 FIKFVDVWTYEMPRDTCLSYSPLLQNMIDEFSDYFLSLCKDVVSNKELMTKL---QESKFDVLLS 151

  Fly   131 DLWRMDVLSG---LAAYFDAPIIGMASYGTDWKIDELMGN-VSPISYLQSPSSRFYDLEAYGERL 191
            |    .|.|.   :|.....|.:....:...::|::..|. :.|.||:....|.......:.||:
Mouse   152 D----PVASCGELIAELLQIPFLYSIRFSPGYQIEKSSGRFLLPPSYVPVILSGLGGQMTFIERI 212

  Fly   192 LHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAERKPLSEISRNFDLVLVNQHFTLGPPRPYVPN 256
            .:::...:....::..:.:|.::.||::   :.....|.|.....::.|:..::.|..|.|.:||
Mouse   213 KNMICMLYFDFWFQMFNDKKWDSFYSEY---LGRPTTLVETMGQAEMWLIRSNWDLEFPHPTLPN 274

  Fly   257 MIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDRRKVLLETFASLPQRI 321
            :..|||||. ...:.|..:::.|:|.:|:.||:.||||:.|  .:::|::...:....|.:||::
Mouse   275 VDYVGGLHC-KPAKPLPKDMEEFVQSSGDHGVVVFSLGSMV--SNMTEEKANAIAWALAQIPQKV 336

  Fly   322 VWKFEDELLPGKPP-----NVFISKWFPQQAILAHPNVKLFITHGGLLSTIESIHHGKPMLGLPC 381
            :|||:     ||.|     |..:.||.||..:|.||..|.|:||||.....|:|:||.||:|:|.
Mouse   337 LWKFD-----GKTPATLGHNTRVYKWLPQNDLLGHPKTKAFVTHGGANGVYEAIYHGIPMIGIPL 396

  Fly   382 LFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARYRDQPMKPMETA 446
            ..:|..|:.|:...|..:.|||:.|:..:..:.:..::.|..:::.|...:..:.||||||::.|
Mouse   397 FGEQHDNIAHMVAKGAAVALNIRTMSKSDVLNALEEVIENPFYKKNAMWLSTIHHDQPMKPLDRA 461

  Fly   447 IWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFL--VGALVILGIVTYLLVMTLRKCLFLI 509
            ::|.|:|:.||.|.|::..|.:|.:.:||||||.|..|  |...::|.:          |||..|
Mouse   462 VFWIEFVMRHKRAKHLRPLGHNLTWYQYHSLDVIGFLLSCVATTIVLSV----------KCLLFI 516

  Fly   510 KR 511
            .|
Mouse   517 YR 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	126/469 (27%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	141/513 (27%)
Ugt2b5	NP_033493.3	egt	8..489	CDD:223071	129/481 (27%)
Ugt2b5	NP_033493.3	UDPGT	24..527	CDD:278624	144/522 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840417
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690