DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35D1 and ugt-3

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_506203.2	Gene:	ugt-3 / 191174	WormBaseID:	WBGene00013903	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	538	Identity:	129/538 - (23%)
Similarity:	229/538 - (42%)	Gaps:	58/538 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLVCLLPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSP-----YPQREPFRNIH 65
            ||:...| .:.|...|.:.|:...||..|.......||..||.:|...|     |..::..:|.:
Worm     5 LLLAFFP-VAFGFNYLIISPVFGYSHMKFMGRIADILADAGHNVTLFQPIIYDYYAHKKIVKNPN 68

  Fly    66 -DIPVPEVFENFNEVLRIASTPRSTWQ---SSDFINEYVLNLTKTVLNNEGVRRDILGPQKPH-- 124
             ::...||.|........||..:..|:   |.:.|:...:...|.....|.:.|.:|..::.|
Worm    69 IEVINYEVDEEEKAAASEASVFKFFWKAKGSKNPISSAKITSEKLYKEFEHICRKMLLDKELHRW 133

  Fly   125 -----FDLVIMD------LWRMDVLSGLAAYFDAPI-------IGMASYGTDWKIDELMGNVSPI 171
                 ||..|.:      |:..|.|.     ..:||       .|.|||.        :|...|:
Worm   134 ILSKNFDSHISEAFDFCGLYLGDFLK-----LKSPIPLYSGVRCGAASYA--------VGEPIPL 185

  Fly   172 SYLQSPSSRFYDLEAYGERLLHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAERKPLSEISRNF 236
            :||.:..|.:....:..:||..::..|..:..:.....::.:..|.....:|   :...||.::.
Worm   186 NYLPTEGSNYGKKSSAIDRLSDMLGLTGYHFQFGILFDKQYDQAYRLTGGNV---RTWQEILQSS 247

  Fly   237 DLVLVNQHFTLGPPRPYVPNMIQVGGLHVD-HSTEALSAELDHFIQGAGESGVIYFSLGTNVKSK 300
            ...|.|.:..|....|.:..:||:||..:: ..|..|..|.:..:  :..:..|..|.||.::|.
Worm   248 TFFLTNSNPYLSFSTPTISKVIQIGGFTIESFKTTTLDEEFNKIL--SLRNNTILVSFGTVIQSS 310

  Fly   301 SLSEDRRKVLLETFASLPQ-RIVWKFE--DELLPGK-PPNVFISKWFPQQAILAHPNVKLFITHG 361
            .:.:|.:..|:|.|..:|. ..:||:|  |:.|..| ..||.:|||.||.|:||...:.||:|||
Worm   311 DMPDDFKTGLIEAFRRMPDATFIWKYEEDDKTLKNKLSENVVLSKWIPQPALLADSRLDLFVTHG 375

  Fly   362 GLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLN-IKQMTSEEFRSTIIRLLTNKSFE 425
            ||.||:|..:.|...:.:|...||..|.:.:.:.|..:|.: ...:.|::...||..:|.|..:.
Worm   376 GLGSTMEVGYAGVSSIMVPVFSDQGVNAEMLARHGGAIVYDKFDLVDSKKLMETIQMILNNSDYR 440

  Fly   426 ETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLD----VFGTFLVG 486
            :.::..:....:|||.|.:..:...|:........:::.......|:.::.||    |..|..|.
Worm   441 KNSKRLSDILHNQPMDPKQVLLNHCEFAARFAQVDNLEPYANKYNFIEFYCLDSLALVVCTISVV 505

  Fly   487 ALVILGIVTYLLVMTLRK 504
            |||:..|:::::...:.|
Worm   506 ALVMFKILSFVVNSVIEK 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	118/490 (24%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	123/514 (24%)
ugt-3	NP_506203.2	egt	1..457	CDD:223071	116/470 (25%)
ugt-3	NP_506203.2	UDPGT	27..525	CDD:278624	123/515 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810