DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and ugt-37

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_504811.2	Gene:	ugt-37 / 184293	WormBaseID:	WBGene00017332	Length:	528	Species:	Caenorhabditis elegans

Alignment Length:	547	Identity:	128/547 - (23%)
Similarity:	213/547 - (38%)	Gaps:	87/547 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IFLLVCLLPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRNIH--- 65
            |.|..|....:|....|.:  ||...||..|......:|:..||.:|..:|...|: |..|:
Worm     5 ILLFACFNVNFSYNFLIFS--PLFGHSHTTFFAKIADTLSEAGHNVTFFTPTIIRK-FSKINYVK 66

  Fly    66 ------DIPVPEVFENFNEVLRIASTPRSTWQSSDFINEYVLNLTKTVLNNE---------GVRR 115
                  .:...|..|.:...:......| .|.....:.| :..:.|  |.||         |...
Worm    67 HTKHVIHLEPSEKLERYGNQMEDVDISR-FWTDDSSMAE-MFPMIK--LFNEMFAEQAFVLGQNL 127

  Fly   116 DILGPQKP-HFDLVIMDLWRMDVLSGLAAYFD-APIIGMASYGTDWKIDELMGNVSPISYLQSPS 178
            |:|...|. .||::|.:.: .:....|..|.: ...|..:|...|..:...:|.....|.:..|.
Worm   128 DVLDELKEMKFDVMIFERF-AECAYPLLEYLEIETFIPSSSLLFDPNLLISIGEPRIPSTVPLPM 191

  Fly   179 SRFYDLEAYGERLL--------HLMERTFSYMN----YKWRHVRKQETLYSQFFPSVAERKPLSE 231
            |:|.|.....||||        |.:..|..:.:    |:...::|.|.|.|
Worm   192 SKFTDKMTMTERLLNAIAVPIFHSLLPTHEFKSFRPPYQAIDIQKMEHLSS-------------- 242

  Fly   232 ISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHST---EALSAELDHFIQGAGESGVIYFSL 293
                  .:|.|.:..:..|||.:...:|:||:.||...   ..::.|.|..:....::  |..|.
Worm   243 ------FILSNSNPYIDYPRPTLEKNVQIGGISVDVENLKIHKVNEEWDRILDMRQKT--ILVSF 299

  Fly   294 GTNVKSKSLSEDRRKVLLETFASLPQ-RIVWKFE---DELLPGKPPNVFISKWFPQQAILAHPNV 354
            |:.:.||.:..:.:|:|.:|....|: ..:||:|   .:|...:..|:..|.|.||.|:||...:
Worm   300 GSVMLSKDMPVENKKILAKTMKQFPEVTFIWKYEFNDTDLFASETENIHFSSWVPQTALLADRRL 364

  Fly   355 KLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMD---------HVRQVGLGLVLNIKQMTSEE 410
            ..|.||.||.|..|..:.|||.:..|...||.||..         .:.:..||        ..|:
Worm   365 TAFFTHAGLGSVNEVSYLGKPSIMCPIFADQMRNAKMLARHNGSIEISKYDLG--------NGEK 421

  Fly   411 FRSTIIRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYH 475
            ...|:..:|.:.|:..:|...|.:..:||:||.|..:...|:.........:....:.|.||.|.
Worm   422 IEKTLRTILFDDSYRLSAEKLAHQLANQPVKPKELLLRHAEFAAQFGRLPSLDPYSRQLSFVEYF 486

  Fly   476 SLDVFGTFLVGALVILGIVTYLLVMTL 502
            .:||....:..:|:|: :|.:.::..|
Worm   487 LIDVAAILIFSSLLIV-VVLFQIIKRL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	118/505 (23%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	121/521 (23%)
ugt-37	NP_504811.2	Glycosyltransferase_GTB_type	1..504	CDD:299143	126/537 (23%)
ugt-37	NP_504811.2	UDPGT	37..510	CDD:278624	117/509 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810