DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35D1 and ugt-1

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_505671.1	Gene:	ugt-1 / 179449	WormBaseID:	WBGene00007072	Length:	529	Species:	Caenorhabditis elegans

Alignment Length:	571	Identity:	134/571 - (23%)
Similarity:	226/571 - (39%)	Gaps:	101/571 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPPIFLLVCLLPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRNIH 65
            |..:|||:..|. :......|.|.|:...||..|......:||:..|.:|.:..| ..|.|..|
Worm     1 MKILFLLLTSLT-FCYSHNFLVVSPVFGYSHMKFMNKVADTLANGDHNVTILQTY-NYEHFGKI- 62

  Fly    66 DIPVPEVFENFN-EVL-------------RIASTPRSTWQSSDFINEYVLN--LTKTVLNNEGVR 114
                 .:.:|.| |:|             ..||..:..| :::.||..:..  .|.|||
Worm    63 -----RMAKNTNVEILDYHLDESKAVSNENSASAFKYMW-NTEIINNPITGAIATSTVL------ 115

  Fly   115 RDILGPQKPHFDLVIMD--LWRMDVLSGLAAYFDAPIIGMASY-GTDWKIDEL------------ 164
               .|..|...:.|::|  |.:..:......:...|......| |...|::.:
Worm   116 ---YGEMKTMCEKVLLDKKLHKWILSKNFDGFISEPFDFCGLYLGDHLKLNIIPMHSSTKSLPSV 177

  Fly   165 --MGNVSPISYLQSPSSRFYDLEAYGERL-----LHLMERTFSYM---NYK------------WR 207
              :|..|.:::|.|..::|...:...:|:     |..:|..||.:   .||            |:
Worm   178 YAIGEPSLLNFLPSMRTKFGTEQTVFDRIGDIIALPCLELAFSKLFEKQYKQASQLLNGDVRHWK 242

  Fly   208 HVRKQETLYSQFFPSVAERKPLSEISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEAL 272
            .:.:..|.|                       ..|.:..:..|.|.:|..:.:||..:|......
Worm   243 EILQTATFY-----------------------FSNANDFIAFPTPSLPKHVHIGGFTIDPPKNLK 284

  Fly   273 SAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDRRKVLLETFASLPQ-RIVWKFE---DELLPGK 333
            ..|..:.|....:|.|: .|.||.::|..:.|..:..:::.|..||. ..:||:|   .:.:...
Worm   285 LEEEYNKILSLRKSTVL-ISFGTVIQSADMPESFKDGIIKMFHLLPDTTFIWKYEVEDQQFIERL 348

  Fly   334 PPNVFISKWFPQQAILAHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLG 398
            |.|..:.||.||.|:||.|.:|||:|||||.||:|..:.|||.|.:|...||..|...:.:.|..
Worm   349 PNNAILKKWVPQPALLADPRLKLFVTHGGLGSTLEVAYSGKPALMIPVFGDQLLNAKMLSRHGGA 413

  Fly   399 LVLNIKQM-TSEEFRSTIIRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHM 462
            .|.:...: .:|:..|.|..::.|:.|.:.:...|...|:||:.|....:...|:.........:
Worm   414 TVFDKYDLEDAEKLTSAIKEIIGNEEFNKKSHHIADLLRNQPIDPKANLLKHVEFSAKFGRVDAL 478

  Fly   463 QVAGKDLGFVRYHSLDVFGTFLVGALVILGIVTYLLVMTLRKCLFLIKRGK 513
            :.......||:|:.||.| ..:...|:|:..:.:||...:.|.:|..|..|
Worm   479 EPYNVHYNFVQYYMLDAF-AIIFSILIIIFYLAHLLFKFVYKHVFKTKSKK 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	120/518 (23%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	124/538 (23%)
ugt-1	NP_505671.1	UDPGT	28..528	CDD:278624	125/541 (23%)
ugt-1	NP_505671.1	egt	<190..494	CDD:223071	79/327 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810