DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35D1 and ugt-49

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_505666.2	Gene:	ugt-49 / 179446	WormBaseID:	WBGene00007070	Length:	525	Species:	Caenorhabditis elegans

Alignment Length:	560	Identity:	140/560 - (25%)
Similarity:	234/560 - (41%)	Gaps:	88/560 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IFLLVCLLPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITS-VSPYPQREPFRNIHDI 67
            :|||:.||.  .:..:||...|..|.||.........:|...||::.. ::.|   ||.......
Worm     5 LFLLLSLLA--VDAGKILVYSPSISRSHLISNGRIADALVDAGHDVVMFITEY---EPLTEFTGT 64

  Fly    68 PVPEVFENFNEVLRIASTPRSTWQSSDFINEYVLNLTKT--------------VLNNEGVRRDIL 118
            ...:|.     .::..||..:  :..|.|.||:|:.::.              ..::...||:.|
Worm    65 KKAKVI-----TMKGFSTKFA--EDMDGIGEYLLSSSRLSFLERLMFEKTCTGACDDLMTRREEL 122

  Fly   119 GPQKPH-FDLVIMDLWRMDVLS-GLAAYF---------DAPIIGMASYGTDWKIDELMGNVSPIS 172
            ...:.: ||:...:  ::|:.. |:..|.         ..||:...||.        :|..:|.|
Worm   123 EQLRAYNFDVAFSE--QIDLCGVGIVRYLGIKNHLWISTTPIMDAVSYN--------LGIPAPSS 177

  Fly   173 YLQSPSSRFYDLEAYGERLLHLMERTFS-YMNYKWRHVRKQET--------LYSQFFPSVAERKP 228
            |:  |:....|   .|:: :...:|||: ||......:.:..|        .|...||:|
Worm   178 YV--PTIEEND---NGDK-MDFWQRTFNLYMKIGSILIHRYGTDGTTEVFRKYIPDFPNV----- 231

  Fly   229 LSEISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSL 293
             .||:.|..|..||....|..|||.:...|.||||.:...::.|..:..: |...|:.||:..||
Worm   232 -REIAANSSLCFVNSDEVLDLPRPTITKAIYVGGLGIPKVSKPLDKKFTN-IMSKGKEGVVIISL 294

  Fly   294 GTNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKP---------PNVFISKWFPQQAIL 349
            |:.:....|....::.:|.....:..   :.|..::..|..         .||.:::|.||..||
Worm   295 GSIIPFGDLPAAAKEGVLRAIQEISD---YHFLIKIAKGDNNTKKLVEGIKNVDVAEWLPQVDIL 356

  Fly   350 AHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRST 414
            :||.:|||:.|||:...:|:.....|.:.:|...|||||...|.:.|:|.||....:..|.|::|
Worm   357 SHPRLKLFVMHGGINGLVETAIQAVPTVIVPVFADQFRNGRMVEKRGIGKVLLKLDIGYESFKNT 421

  Fly   415 IIRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDV 479
            ::.:|...|:::.|.......||:|..|.|....||::.:.|.....:.|.|..|..:.|::|||
Worm   422 VLTVLNTPSYKKNAIRIGKMMRDKPFSPEERLTKWTQFAIDHGVLEELHVEGSRLNTIIYYNLDV 486

  Fly   480 FGTFLVGALVILGIVTYLLVMTLRKCLFLIKRGKCEAIKK 519
            ....|...:.:|.:..|..     |.|...||.:.. |||
Worm   487 IAFVLFVFVAVLHVFIYAF-----KFLCCKKRSQSN-IKK 520

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	123/501 (25%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	126/524 (24%)
ugt-49	NP_505666.2	UDPGT	17..523	CDD:278624	135/546 (25%)
ugt-49	NP_505666.2	egt	<162..464	CDD:223071	88/325 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14680
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	5.710