DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and ugt-11

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_504311.1	Gene:	ugt-11 / 178882	WormBaseID:	WBGene00020593	Length:	533	Species:	Caenorhabditis elegans

Alignment Length:	534	Identity:	129/534 - (24%)
Similarity:	230/534 - (43%)	Gaps:	60/534 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 FLLVCLLPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRNIHDIPV 69
            |..:|.|...:..|:||...|:...||..|.......:|..|.|:|...|:  ....:|:..|..
Worm     6 FSCLCFLLKVNYAAKILIFNPIFGFSHVKFVSKLADIIADHGQEVTLFQPF--HLALKNLDGIVK 68

  Fly    70 PEVFE-------NFNEVLRIASTPRSTWQSSDFINEYVLN--LTKTVLNNEGVR--------RDI 117
            .:..|       :::::|::.:.....:..|..:|..||.  :...:|..|..:        ::|
Worm    69 NKNIEIINYYPDHYDDLLKLETQTFPDFWDSQLMNNPVLMAFMLPRILGGEFKKTTIQLIKDKEI 133

  Fly   118 LGPQK-PHFDLVIMDLWRMDVLSG--LAAYFDAPIIGMASYGTDWKIDELMGNVSPISYLQSPSS 179
            |...| ..||:.|.:.:.   |:|  ::.:...|.|.:.|.......:|..|..|...||....|
Worm   134 LKKLKDKKFDVAISETFE---LTGMYMSHFLGVPCIPILSAVRLDIFNEAFGQSSAFGYLTQQGS 195

  Fly   180 RFYDLEAYGERLLHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAERKPLSEISRNFDLV----- 239
            :......:.:||..:....||.|.::.         .:|:...|.|:.....:....|||
Worm   196 KLAPDAGFLDRLNDVYRDFFSKMAFRG---------MAQYQNDVIEKAAGHVVPYWKDLVKEAPV 251

  Fly   240 -LVNQHFTLGPPRPYVPNMIQVGGL--------HVDHSTEALSAELDHFIQGAGESGVIYFSLGT 295
             :.|.:..|....|....::.:||:        |||    ||..|.:..::  .:...:..|.|:
Worm   252 YMTNSNPYLDFAVPTTATIVHIGGITINLEKMNHVD----ALPEEYEIILK--EKETTVLISFGS 310

  Fly   296 NVKSKSLSEDRRKVLLETFASLPQRI-VWKFE-DELLPGK--PPNVFISKWFPQQAILAHPNVKL 356
            .::|..:.|:.:..|::.|.|||..| :||:| |:|...|  |.||.:.||.||.::||...|||
Worm   311 VIRSYEMPENFKAGLIKVFESLPDVIFIWKYEIDDLEFQKKLPKNVHLKKWVPQPSLLADKRVKL 375

  Fly   357 FITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLN-IKQMTSEEFRSTIIRLLT 420
            |:|||||.||:|..:.|||.|.:|...||..|.|.:.:.|..:..: ...:..::...|:..|:|
Worm   376 FVTHGGLGSTMEVAYTGKPALMVPIFGDQPMNADMLARHGGAIAYDKFDLVDGKKLTETVRDLVT 440

  Fly   421 NKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLV 485
            |..:|:.|:.......:||:.|:...:...|:.:..............:|.:.::.|||. .||:
Worm   441 NPKYEQKAKELLDVLTNQPIDPVMNLMKHLEFAIKFPNLRSQIPEINQVGPIAHYYLDVI-VFLI 504

  Fly   486 GALVILGIVTYLLV 499
            ...:|...:::.:|
Worm   505 FVSIITAYISFQIV 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	121/495 (24%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	122/509 (24%)
ugt-11	NP_504311.1	egt	<220..514	CDD:223071	81/309 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.810