DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ugt35D1 and ugt-12

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_504309.1	Gene:	ugt-12 / 178880	WormBaseID:	WBGene00020592	Length:	534	Species:	Caenorhabditis elegans

Alignment Length:	553	Identity:	150/553 - (27%)
Similarity:	241/553 - (43%)	Gaps:	75/553 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IFLLVCL-LPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRNIHDI 67
            ||||..| ...||  ::||...|:...||..|.......:|..||.:|...||  ....:|:..:
Worm     7 IFLLTFLFFECYS--SKILIFNPIFGFSHVKFISKMADIIADHGHHVTLFQPY--HIALKNLDGL 67

  Fly    68 PVPEVFE-------NFNEVLRIASTPRSTWQSSDFINEYVLN--LTKTVLNNE--GVRRDILGPQ 121
            ...:..|       ::.|:|:......|.:..|..:...|:.  |...:|..|  ....::|..|
Worm    68 VKNKNIEILNYHPTHYEELLKAEPQTFSFFWDSYLVGNPVIGAFLMPKLLGGEFKKTAMEVLSDQ 132

  Fly   122 K-------PHFDLVIMDLWRMDVLSG--LAAYFDAPIIGMAS------YGTDWKIDELMGNVSPI 171
            |       ..|||||.:.:.   |:|  ||...|.|.|.|.|      :...:....|:|:|..|
Worm   133 KLINELKDRKFDLVIAETFE---LTGFYLAHLLDVPCIPMMSAVRYPIFNDQFGQPSLLGHVPQI 194

  Fly   172 SYLQSPSSRFYDLEAYGERLLHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAERKPL---SEIS 233
            ....:..:.|||      ||..:..  |.:|......:.|    |..:|...|..:|:   .::.
Worm   195 GSAVAGEAGFYD------RLNDMFR--FFFMGISQEQLNK----YQNYFIEEAIGRPVPFWKDLV 247

  Fly   234 RNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVD----HSTEALSAELDHFIQGAGESGVIYFSLG 294
            :...:.:.|.:..|....|....::||||:.:|    .....|..|.::.:: ..||.|: .|.|
Worm   248 KQSPIYITNSNPYLDYAVPSTAAIVQVGGITMDLKKLKQVGELPEEYENILK-ERESTVL-ISFG 310

  Fly   295 TNVKSKSLSEDRRKVLLETFASLPQ-RIVWKFE-DELLPGK--PPNVFISKWFPQQAILAHPNVK 355
            :.::|..:.|..:..|::.|.|||. ..:||:| |:|...|  |.||.:.||.||.::||...||
Worm   311 SVIRSYEMPESFKAGLIKVFESLPDVTFIWKYEKDDLEFQKRLPKNVHLKKWIPQPSLLADKRVK 375

  Fly   356 LFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLV----LNIKQMTSEEFRSTII 416
            ||||||||.||:|..:.|||.:.:|...||..|...:.:.| |.|    .::|  ..|:..:.:.
Worm   376 LFITHGGLGSTMEVAYTGKPAIVVPIFGDQHHNAVMLARHG-GAVAYDKFDLK--NGEKLTAVVH 437

  Fly   417 RLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFG 481
            .::::..::|.|........:||:.|....:...::.:..........|...||||.::.|||..
Worm   438 EMISSTKYQENAEALQHVLFNQPIDPKMNFLNHLDFAIKFPNHRAQVPAINQLGFVAHYYLDVLL 502

  Fly   482 TFLVGALVILGIVTYLLVMTLRKCLFLIKRGKC 514
            ..||.::||    |||.:..|:|.|     |||
Worm   503 FLLVSSIVI----TYLAISLLKKVL-----GKC 526

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	129/499 (26%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	137/521 (26%)
ugt-12	NP_504309.1	MGT	28..453	CDD:273616	116/446 (26%)
ugt-12	NP_504309.1	egt	<132..514	CDD:223071	112/405 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810