DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and ugt-45

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_500410.2	Gene:	ugt-45 / 177139	WormBaseID:	WBGene00021372	Length:	527	Species:	Caenorhabditis elegans

Alignment Length:	553	Identity:	129/553 - (23%)
Similarity:	234/553 - (42%)	Gaps:	93/553 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IFLLVCLLPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRNIHDIP 68
            :|||:.:||..| ..:||...|....||..........|...||::|.:.|.          |:|
Worm     5 VFLLLFVLPAAS-CYKILVSVPKFGFSHMQTMGKLADILVEAGHDVTFLMPV----------DVP 58

  Fly    69 VPEVFENFNEVLRIASTPRSTWQSSDFINEY---------VLNL-TKTVLNNEGV--RRDILGPQ 121
            :|   :|..|:.::...|     ::|.|||.         |.|| |.:..:.:|:  ..|::|..
Worm    59 IP---QNGTELAKVVLVP-----TTDAINEIMGHAMKSGAVANLWTHSANSKQGIMWSTDMIGQV 115

  Fly   122 KPH-------------------FDLVIMDLWRMDVLSGLAAYFDAPIIG----MASYGTDWKIDE 163
            ..|                   ||:.|.:|:.   .||| |:|:  :||    |.::.|......
Worm   116 SYHNTKNLIDNKALVQQMKDEKFDIGITELFD---FSGL-AFFE--VIGLKNVMGAHTTSVFEGT 174

  Fly   164 LMGNVSPISYLQSPSSRFYDLEAYGERLLHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAERKP 228
            ||...:||.....|:|:.:..:: |..|..|.....:|.:|::     |..:.|....::.|...
Worm   175 LMATGAPILPSFVPASQTFTDDS-GSILSRLNNLYMTYWSYQF-----QNKIQSFAQKALDEHYE 233

  Fly   229 LSEISRNFDLV------LVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESG 287
            ..:..:.::||      .||.......|:|...|::::.|:.|. ..:.:..|.|..:....::
Worm   234 KGKAPKIWNLVSDITWFFVNSDPIFDFPKPLPQNIVEIAGISVP-EIKPVGKEWDEILSKRSKN- 296

  Fly   288 VIYFSLGTNVKSKSLSEDRRKVLLETFASLPQ-RIVWKFED--ELLPGKPPNVFISKWFPQQAIL 349
             :..|.|:.....::.|..:|.:::.||:.|. ..:||::|  ..|.....||.|.||.||..:|
Worm   297 -VLVSFGSIASPTTMPEAVKKSIVDAFAAFPDVTFIWKYDDTESKLTAHLDNVHIVKWMPQNDLL 360

  Fly   350 AHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMT-SEEFRS 413
            |...:.:|.||||:.|.:||.....|::.:|...||.||....::.|:.|:.:...:: :::...
Worm   361 ADKRISMFWTHGGMGSLMESAQKSVPLVVVPIFGDQMRNAQIAKRHGVALIYDKMDLSNTKKLIG 425

  Fly   414 TIIRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLD 478
            .:..:|.|..::::|.:.|.....:...|.:..|...|.............|||:..|::|.:||
Worm   426 ALKEVLENPEYKKSAELLARILATERFSPRQKIIDTVEMAGRFGQMPRWTSAGKEFSFLKYFNLD 490

  Fly   479 VFGTFLVGALVILGIVTYLL-----VMTLRKCL 506
                     |||:.:..:.|     |:.:|..|
Worm   491 ---------LVIIAVFIFFLSIVSTVLLIRHLL 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	115/502 (23%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	120/527 (23%)
ugt-45	NP_500410.2	egt	14..513	CDD:223071	123/541 (23%)
ugt-45	NP_500410.2	UDPGT	19..510	CDD:278624	121/532 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm14613
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.810