Protein Alignment Ugt35D1 and UGT3A2

DIOPT Version :10

• Sequence 1: NP_651866.1
• Gene: Ugt35D1 / 43708
• FlyBaseID: FBgn0051002
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: XP_011512290.1
• Gene: UGT3A2 / 167127
• HGNCID: 27266
• Length: 550
• Species: Homo sapiens
• Alignment Length: 578
• Identity: 154/578 - (26%)
• Similarity: 248/578 - (42%)
• Gaps: 125/578 - (21%)

  Fly     4 IFLLV-CLLPG--YSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEIT--------------- 50
            :.||| .||||  .||.|:||.:..: ..|||.......:.|...||.:|
Human     6 VLLLVGFLLPGVLLSEAAKILTISTV-GGSHYLLMDRVSQILQDHGHNVTMLNHKRGPFMPGLSD 69

  Fly    51 ---SVSPYP----------------------------------QREPFRNIHDIPVPEV------ 72
               |.|.||                                  ||| |:...|..:.|.
Human    70 SPASASRYPRILYLQKYCQFGLKDFKKEEKSYQVISWLAPEDHQRE-FKKSFDFFLEETLGGRGK 133

  Fly    73 FENFNEVLRIASTPRSTWQSSDFINEYVLNLTKTVLNNEGVRRDILGPQK-PHFDLVIMDLWRMD 136
            |||...||...:.     |.|.|:|                |:||:...| .:||:||::.:  |
Human   134 FENLLNVLEYLAL-----QCSHFLN----------------RKDIMDSLKNENFDMVIVETF--D 175

  Fly   137 VLSGL-AAYFDAPIIGM--ASYGTDWKIDELMGNVSPISYLQSPSSRFYD-LEAYGERLLHLMER 197
            ....| |.....|.:.:  .|:|:   ::  .|...|:||:....|...| ::.:|.....||
Human   176 YCPFLIAEKLGKPFVAILSTSFGS---LE--FGLPIPLSYVPVFRSLLTDHMDFWGRVKNFLM-- 233

  Fly   198 TFSYMNYKWRHVRKQETLYSQFFPSVAE------RKPLSEISRNFDLVLVNQHFTLGPPRPYVPN 256
            .||:       .|:|:.:.|.|..::.|      |..||.:....:|..:|..|.....||.:||
Human   234 FFSF-------CRRQQHMQSTFDNTIKEHFTEGSRPVLSHLLLKAELWFINSDFAFDFARPLLPN 291

  Fly   257 MIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSLGTNVKSKSLSEDRRKVLLETFASLPQRI 321
            .:.|||| ::...:.:..:|::||...|:||.:..:||:.|.: ..:.:..|.:...||.|||.:
Human   292 TVYVGGL-MEKPIKPVPQDLENFIAKFGDSGFVLVTLGSMVNT-CQNPEIFKEMNNAFAHLPQGV 354

  Fly   322 VWKFEDELLPGK---PPNVFISKWFPQQAILAHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLF 383
            :||.:....|..   ..||.|..|.||..:||||:::||:||||..|.:|:|.||.||:|:|...
Human   355 IWKCQCSHWPKDVHLAANVKIVDWLPQSDLLAHPSIRLFVTHGGQNSIMEAIQHGVPMVGIPLFG 419

  Fly   384 DQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKSFEETARITAARYRDQPMKPMETAIW 448
            ||..||..|.....|:.:.:|::.:|.....:.:::.:|.::..|...:...|..|:.|.:..:.
Human   420 DQPENMVRVEAKKFGVSIQLKKLKAETLALKMKQIMEDKRYKSAAVAASVILRSHPLSPTQRLVG 484

  Fly   449 WTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGALV--------ILGIVTYLL 498
            |.::||...||.|::.......:...:.|||| .||:|..:        :||:..:.|
Human   485 WIDHVLQTGGATHLKPYVFQQPWHEQYLLDVF-VFLLGLTLGTLWLCGKLLGMAVWWL 541

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	GT1_Gtf-like	18..449	CDD:340817	129/502 (26%)
UGT3A2	XP_011512290.1	Glycosyltransferase_GTB-type	23..518	CDD:471961	139/536 (26%)