DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and Ugt2b34

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_705826.1	Gene:	Ugt2b34 / 100727	MGIID:	2140962	Length:	532	Species:	Mus musculus

Alignment Length:	562	Identity:	162/562 - (28%)
Similarity:	267/562 - (47%)	Gaps:	95/562 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IFLLVCLLPGY---SEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSP----------- 54
            :.||:..|.|:   ..|.::| |:|: ..||:......|..|...|||:..:.|
Mouse     9 LLLLLLQLSGFFGSGTGGKVL-VWPM-EFSHWLNLKTILDELLKKGHEVMVLRPSASLSYEVDNT 71

  Fly    55 -------YPQREPFRNIHDIPVPEVFENFNEVLR--IASTPRST------------WQSSDFINE 98
                   ||.        ...:.|:.|.|.|.|:  |...|:.:            |..|    :
Mouse    72 SAIEFETYPT--------SYSLSELEEIFWESLKKYIYELPKQSFWGYFLMLQEMVWVDS----K 124

  Fly    99 YVLNLTKTVLNNEGVRRDILGPQKPHFDLVIMDLWRMDVLSG--LAAYFDAPIIGMASYGTDWKI 161
            |..:|.|.|:.|:.:...:   ||..||:::.|.:   :..|  ||.....|::....:......
Mouse   125 YFESLCKDVVFNKELMTKL---QKSRFDVILADPF---IPCGDLLAEVLKIPLVYSLRFFPGSTY 183

  Fly   162 DELMGNVS-PISYLQSPSSRFYDLEAYGER---LLHLMERTFSYMNYKWRHVRKQETLYSQFFPS 222
            ::..|.:. |.||:....|...|...:.||   :::::...|.:..:       .|..::|.:..
Mouse   184 EKYSGGLPLPPSYVPVVMSELSDRMTFMERVRNVIYMLCFDFWFQTF-------NEKNWNQLYTE 241

  Fly   223 VAER-KPLSEISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGES 286
            |..| ..|||.....|:.|:..::.|..|.|.:||...:||||. ...:.|..|::.|:|.:||.
Mouse   242 VLGRPTTLSETMAKADIWLIRTYWDLEFPHPVLPNFDFIGGLHC-RPAKPLPKEIEDFVQSSGEH 305

  Fly   287 GVIYFSLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPP-----NVFISKWFPQQ 346
            ||:.||||:.|  .|::|:|..|:....|.:||:::|:||     ||.|     |..:.||.||.
Mouse   306 GVVVFSLGSMV--GSITEERANVIAAGLAQIPQKVLWRFE-----GKKPETLGSNTRLYKWIPQN 363

  Fly   347 AILAHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEF 411
            .:|.|...:.||||||.....|:|:||.|::|:|...||:.|:.|::..|..:.|:...|:|.:.
Mouse   364 DLLGHSKTRAFITHGGTNGIYEAIYHGIPVVGIPLFGDQYDNIVHLKAKGAAVRLDFLTMSSTDL 428

  Fly   412 RSTIIRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHS 476
            .:.:..:..:.|::|.|...:..:.|||:||::.|::|.|:|:.||||.|::||..||.:|:|||
Mouse   429 HTALKTVTNDPSYKENAMRLSRIHHDQPVKPLDRAVFWIEFVMRHKGAKHLRVAAHDLSWVQYHS 493

  Fly   477 LDVFGTFLVGALVILGIVTYLLVMTLRK-CLF----LIKRGK 513
            |||.|..|...|.::.|        |:| |||    |.|.|:
Mouse   494 LDVLGFLLACVLTVMFI--------LKKCCLFCCQKLTKAGR 527

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	138/504 (27%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	152/529 (29%)
Ugt2b34	NP_705826.1	UDPGT	27..529	CDD:278624	157/544 (29%)
Ugt2b34	NP_705826.1	egt	<272..510	CDD:223071	92/245 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840414
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.690