DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and ugt5b2

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001170970.2	Gene:	ugt5b2 / 100415799	ZFINID:	ZDB-GENE-100406-4	Length:	531	Species:	Danio rerio

Alignment Length:	549	Identity:	149/549 - (27%)
Similarity:	253/549 - (46%)	Gaps:	88/549 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LVCLLPG--YSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEIT-----------SVSPYPQR 58
            |..|||.  .::..::| |||: ..||:......:::|::.||::|           ..||
Zfish    14 LTLLLPSVPVAQCGKVL-VFPV-DGSHWVNMNILVEALSAKGHDVTVMRTASSCYIKEFSP---- 72

  Fly    59 EPFRNIHDIPV---------PEVFENF----NEVLRIAST------PRSTWQSSDFINEYVLNLT 104
                  |...:         .||.|.|    ..:||..||      ....|||...|.|....:.
Zfish    73 ------HYTSINLKSKGGYNKEVLEQFASRIMHILRDGSTWGHLKLQADMWQSFLKIFEAEREMI 131

  Fly   105 KTVLNNEGVRRDILGPQKPHFDLVIMDLWRMDVLSG--LAAYFDAPIIGMASYGTDWK-IDELMG 166
            ..::.::.:.:.:   :...:||::.|   .::..|  |..|...|::    |...|. .:|...
Zfish   132 VNMIEDQQLMQSL---KDAKYDLILTD---PNMFGGVILGHYLKLPMV----YNVRWAGYNEAHF 186

  Fly   167 NV--SPISYLQSPSSRFYDLEAYGERLLHLMERTFSYMNYKWRHVRKQETLYSQFFPSVAER--- 226
            ::  ||:||:..||....|..::       ::|.::.:.|.:..: ....:.|....::|||
Zfish   187 SIAPSPLSYVPMPSLELSDRMSF-------LQRVYNVVMYIFIEI-GAALVISPINDALAERFIG 243

  Fly   227 --KPLSEISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVI 289
              .....:.:..||.|....|....|||.:||:|.:.|.....| :.|..:|:.|:|.:|:.|||
Zfish   244 PGTSFLSLVQGADLWLHRVDFVFEYPRPTMPNVIYMAGFQCKPS-KPLPQDLEDFVQSSGDHGVI 307

  Fly   290 YFSLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPP-----NVFISKWFPQQAIL 349
            ..||||.:  ..|.:|..:.:.|.||.|||:|:|:::     ||.|     |..|..|.||..:|
Zfish   308 IMSLGTLI--DKLPDDVAEAIAEAFAELPQKIIWRYK-----GKRPSALGNNTLIMDWMPQNDLL 365

  Fly   350 AHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRST 414
            .||..:.|:.|||.....|:|:||.|::|...:|||..|:..:|..|....::...|..|.|.:|
Zfish   366 GHPKTRAFVAHGGTNGIQEAIYHGVPIIGFGLIFDQPDNLSKMRVRGAAKNVDFATMNKESFLTT 430

  Fly   415 IIRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDV 479
            :..:|.:.|:.|..:..:..::|.|:||::.||:|.|:|:.||||||::.....:.:..|||:||
Zfish   431 VKEVLYDPSYRENMQRLSRLHKDVPVKPLDNAIFWIEFVMRHKGAAHLRTESYKMPWYSYHSVDV 495

  Fly   480 FGTFLVGA--LVILGIVTYLLVMTLRKCL 506
            . ..|:.|  |:||.|...:.....|.|:
Zfish   496 I-LVLISAVSLIILSIYAVIRYFCCRICM 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	135/501 (27%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	141/524 (27%)
ugt5b2	NP_001170970.2	egt	12..501	CDD:223071	142/525 (27%)
ugt5b2	NP_001170970.2	UDPGT	27..525	CDD:278624	145/536 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584491
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790