DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and ugt5c1

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001170966.1	Gene:	ugt5c1 / 100415793	ZFINID:	ZDB-GENE-050419-68	Length:	531	Species:	Danio rerio

Alignment Length:	556	Identity:	146/556 - (26%)
Similarity:	257/556 - (46%)	Gaps:	106/556 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 IFLLVCLLPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRNIHDIP 68
            ||..:|      :|.:|| |.|| ..||:......:|:|...||.:         :..||.:...
Zfish    20 IFGSLC------DGGKIL-VAPL-EGSHWVNMDILIKALHGQGHTV---------DVIRNTNSWF 67

  Fly    69 VPEVFENFNEVLRIASTPRSTWQSSDFINEYV--------------------LNLTKTV------ 107
            |.|....:|.:    :.|.|.....:|:.:.:                    |:::|.|
Zfish    68 VKENSTYYNSI----TIPDSKGMDEEFVEDVLTKKIDYERGKGSWLGGVQLFLDVSKAVYESHKL 128

  Fly   108 ----LNNEGVRRDIL-GPQKPHFDLVIMDL-WRMDVLSGLAAYFDAPIIGMASYGTDWKIDELMG 166
                :.|.....||| ..|:..:||::.|. |...::  ||.....|::    |...|...   |
Zfish   129 VCRLITNIFESEDILKALQEKKYDLMLTDPGWGTGII--LAHKLKLPMV----YNVRWTTP---G 184

  Fly   167 N------VSPISYLQSPSSRFYDLEAYGERLLHLMERTFSYMNYKWR----HVRKQETLYSQFF- 220
            .      .||:||:....|...|..::.:|::::    |.|:...::    :|.:.:.|..::|
Zfish   185 EGHFDIAPSPMSYIPLTGSGNTDKMSFFQRVINV----FYYLLLDFQCSRFNVPQYQALCDKYFD 245

  Fly   221 PSVAERKPLSEISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGE 285
            |.|...|.|    :..||.|:...|....|||.:||:|..||.... .|:.|..:|:.|:|.:|:
Zfish   246 PPVDFYKLL----QGADLWLMRVDFVFEFPRPTMPNIIYTGGFQCT-PTKPLPHDLEDFMQSSGD 305

  Fly   286 SGVIYFSLGT--NVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPP-----NVFISKWF 343
            .|||..|||:  :|....:|.:    :...||.|||:::|::     .||.|     |..:..|.
Zfish   306 HGVIVMSLGSFISVLPDYVSSE----IAAAFARLPQKVIWRY-----TGKKPSTLGNNTLLVDWM 361

  Fly   344 PQQAILAHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTS 408
            ||:.:|.||..||||.|||.....|:::||.|::|:|..|||:.|:..::..|...::::.::..
Zfish   362 PQKDLLGHPKTKLFIAHGGTNGVQEALYHGVPVIGIPFFFDQYDNLIRLQARGGAKIVSLAELGE 426

  Fly   409 EEFRSTIIRLLTNKSFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVR 473
            ....:.|..::...|:....:..:..:||:|::|:::||:|.|:|:.||||||::.....:.:..
Zfish   427 NSLHAAIQEVINEPSYRLNMQKLSYLHRDKPVEPLDSAIFWIEFVMRHKGAAHLRTESYKMPWYS 491

  Fly   474 YHSLDVFGTFLVGALVILGIVTYLLVMTLR----KC 505
            |||:||..|.:...|:.:    |.:.:|:|    ||
Zfish   492 YHSVDVSVTLIAVVLIFI----YSMFVTVRYLCIKC 523

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	133/507 (26%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	137/530 (26%)
ugt5c1	NP_001170966.1	UDPGT	28..530	CDD:278624	142/542 (26%)
ugt5c1	NP_001170966.1	egt	<267..507	CDD:223071	79/249 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585081
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	1	0.900	-	-		E33208_3BDT1
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.690