DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and ugt2a3

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001170814.2	Gene:	ugt2a3 / 100384900	ZFINID:	ZDB-GENE-080721-22	Length:	532	Species:	Danio rerio

Alignment Length:	543	Identity:	158/543 - (29%)
Similarity:	265/543 - (48%)	Gaps:	70/543 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LLVCLL-----PGYSEGARILAVFPLPSS-SHYFFALPYLKSLASLGHEIT-------SVSPYPQ 57
            ||||||     .|:|  .|:|.   :|.. ||:......:::|....|.:|       ...|:.|
Zfish     6 LLVCLLLCGVDVGWS--GRVLV---MPGEYSHWHNMRAIIEALVDRNHSVTVLVGSSSPTVPHTQ 65

  Fly    58 REPFR------NIHDIPVPEVFENF-----NEVLRIASTPRSTWQSSDFINEYVLNLTKTVLNNE 111
            :..|.      ||.......|:.:|     ||......|..:.:|    :....:.||..|.  :
Zfish    66 KARFDYHVFKVNIEKEEADAVWSDFIYLWMNETATKYETVSNIFQ----VMSRFMTLTDEVC--K 124

  Fly   112 GV-RRDILGP-QKPHFDLVIMDLWRMDVLSGLAAYFDAPIIGMASYGTDWKIDELMGNV-SPISY 173
            |: :.|:|.. ::.|:|::..|. .|.....:|...:.|::........:..:.:.|.: :|.||
Zfish   125 GMFKEDLLQMLRESHYDVLFSDP-MMPCSDLMAQTLNIPLVLSLRATFAYSFERMCGQMPAPPSY 188

  Fly   174 LQSPSSRFY--DLEAYGER----LLHLMERTF--SYMNYKWRHVRKQETLYSQFFPSVAERKP-- 228
            :.:.|.|.:  |..::.||    ||:.....|  .||.:.:      :.:|::.     ..||
Zfish   189 VPAASLRDHLTDRMSFMERVENMLLYFSHDVFFKLYMMFTF------DRIYTEI-----RGKPTT 242

  Fly   229 LSEISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQGAGESGVIYFSL 293
            :.|.....|:.|:..::....|||:.||...|||||. ...:.||.|::.|:|.:|:.||:.|||
Zfish   243 MCETMGKADIWLIRTYWDFEYPRPFPPNFKFVGGLHC-KPAKPLSKEMEEFVQSSGDHGVVVFSL 306

  Fly   294 GTNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPPNVFISKWFPQQAILAHPNVKLFI 358
            |:.:  |:|:.:|...:......:||::||::..:......||..|..|.||..:|.||..|.||
Zfish   307 GSMI--KNLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDWIPQNDLLGHPKTKAFI 369

  Fly   359 THGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTSEEFRSTIIRLLTNKS 423
            ||||.....|:|:||.||:|||...||..|:.|::..|..:||:|..:.|::....:..:|.|.|
Zfish   370 THGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKDLVDALKTVLNNPS 434

  Fly   424 FEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFVRYHSLDVFGTFLVGAL 488
            ::|:....:..:.||||||::.|::|.|:|:.:|||.|::|...:|.:.:||.||| ..||   |
Zfish   435 YKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYHCLDV-AAFL---L 495

  Fly   489 VILGIVTYLLVMTLRKCLFLIKR 511
            .|..::|:|.|   :.|.||.:|
Zfish   496 SIAALITFLWV---KACCFLFRR 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	139/492 (28%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	146/511 (29%)
ugt2a3	NP_001170814.2	UDPGT	21..519	CDD:278624	150/526 (29%)
		REC	<129..>178	CDD:302758	8/49 (16%)
		egt	<254..485	CDD:223071	84/233 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170585009
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H55988
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.930