DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt35D1 and ugt5e1

DIOPT Version :9

Sequence 1:	NP_651866.1	Gene:	Ugt35D1 / 43708	FlyBaseID:	FBgn0051002	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_005166829.1	Gene:	ugt5e1 / 100002993	ZFINID:	ZDB-GENE-081105-106	Length:	590	Species:	Danio rerio

Alignment Length:	566	Identity:	156/566 - (27%)
Similarity:	260/566 - (45%)	Gaps:	93/566 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 PPIFLLVCL---LPGYSEGARILAVFPLPSSSHYFFALPYLKSLASLGHEITSVSPYPQREPFRN 63
            |.|.:||..   ||..|...:|| |:|: ..||:......|:.|...||::|.|         |:
Zfish    63 PQISVLVAFIWSLPSLSLAGKIL-VYPV-DGSHWLNMNILLQELHQRGHKLTVV---------RS 116

  Fly    64 IHDIPVPEVFENFNEV------LRIASTPR-----------------STWQSSDFINEYV----- 100
            .:...:||...::..:      |.....|:                 |.|.......|.:
Zfish   117 ANSWYIPENATHYTSITIQVNHLSSLEDPKYMASFLKRNIDIQRGKGSIWSFLALQKEIITLLEE 181

  Fly   101 -----LNLTKTVLNNEGVRRDILGPQKPHFDLVIMDLWRMDVLSG---LAAYFDAPIIGMASYGT 157
                 ..:.:.||.:|.:.:.:   ::..:||::.|    ...:|   |.||...|::    :..
Zfish   182 SHRSTAEMVRVVLEDEKLIKTL---KESKYDLMLTD----PGFAGGVILGAYLGLPMV----FNV 235

  Fly   158 DWKIDELMGNV----SPISYLQSPSSRFYDLEAYGERLLHLMERTF-SYMNYKWRHVRKQETLYS 217
            .| |....|:.    ||:||:.:..||..|..::..:|.::|.... .|:::.......|..:..
Zfish   236 RW-ITNAEGHFAIAPSPLSYIPTIGSRVTDKMSFANKLKNIMHFGIGQYIDHMLTRPLYQGVISK 299

  Fly   218 QFFPSVAERKPLSEISRNFDLVLVNQHFTLGPPRPYVPNMIQVGGLHVDHSTEALSAELDHFIQG 282
            ...|:.    .:..:.:..||.|:...|....|||.:||::.:||.....| :.|..||:.|::.
Zfish   300 YIDPNT----NVYALIQGADLWLMRVDFVFEFPRPTMPNVVYIGGFQCKPS-KPLPDELNKFVES 359

  Fly   283 AGESGVIYFSLGTNVKSKSLSEDRRKVLLETFASLPQRIVWKFEDELLPGKPP----NVFISKWF 343
            :||.||:..||||.:  .||..|..:::...||.|||:::|:...|    ||.    |..:..|.
Zfish   360 SGEHGVVIMSLGTLL--GSLVPDISEIVASAFAQLPQKVIWRHVGE----KPSTLGNNTLVVDWL 418

  Fly   344 PQQAILAHPNVKLFITHGGLLSTIESIHHGKPMLGLPCLFDQFRNMDHVRQVGLGLVLNIKQMTS 408
            ||..:|.||..|.|:||||.....|:|:||.||||||.:||||.|:..:...|:..:|::..:..
Zfish   419 PQNDLLGHPKTKAFVTHGGTNGIYEAIYHGVPMLGLPLIFDQFDNIIRLEARGVARMLDVATLDV 483

  Fly   409 EEFRSTIIRLLTNK-SFEETARITAARYRDQPMKPMETAIWWTEYVLSHKGAAHMQVAGKDLGFV 472
            :.....:..:|..| |:::..|..::.:||.|:||:::||:|.|:|:.||||||::.....|.:.
Zfish   484 DILTQALKDILDEKQSYQKNMRKMSSLHRDTPLKPLDSAIFWLEFVMRHKGAAHLRTESYKLPWY 548

  Fly   473 RYHSLDVFGTFL-----VGALVILGIVTYLLVMTLRKCLFLIKRGK 513
            .||.|||....:     .|.|:||  ::..|   ||.|:..||..|
Zfish   549 SYHCLDVLALIMSLCTAAGLLLIL--ISRAL---LRACVRKIKAKK 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt35D1	NP_651866.1	egt	1..462	CDD:223071	138/508 (27%)
Ugt35D1	NP_651866.1	UDPGT	30..511	CDD:278624	143/531 (27%)
ugt5e1	XP_005166829.1	UDPGT	82..586	CDD:278624	146/542 (27%)
ugt5e1	XP_005166829.1	egt	<324..550	CDD:223071	83/232 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170584405
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.790