DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG1607 and slc7a6

DIOPT Version :9

Sequence 1:	NP_001263139.1	Gene:	CG1607 / 43707	FlyBaseID:	FBgn0039844	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	XP_005166451.1	Gene:	slc7a6 / 57957	ZFINID:	ZDB-GENE-000607-21	Length:	494	Species:	Danio rerio

Alignment Length:	491	Identity:	224/491 - (45%)
Similarity:	338/491 - (68%)	Gaps:	15/491 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 LNRKNSSRKSSIVNGNGDASAKLTNGDGDGGGDGGGEVTLKAKMSLLNGCTVIVGSIIGSGIFVS 70
            :.....|:|   :||..::.|.|:.        ....:.||.::|||||.::|||::||||||||
Zfish     1 MENNTDSKK---MNGQPESPAALSK--------PRESMQLKKEISLLNGVSLIVGNMIGSGIFVS 54

  Fly    71 PTGVLMYTGSVNLALIVWVISGLFSMVGAYCYAELGTMITKSGADYAYIMETFGPFMAFIRLWIE 135
            |.|||:|:.|..|:|::|.|.|:||:|||.|||||||.||||||.||||:|:||.|:||||||..
Zfish    55 PKGVLIYSASYGLSLVIWAIGGIFSVVGALCYAELGTTITKSGASYAYILESFGGFIAFIRLWTS 119

  Fly   136 CMIVRPCSQAIVALTFSTYVLKPFFPECTPPEDSARLLAVCCILVLTLINCWDVKWATAVQDIFT 200
            .:|:.|.|||::|:||:.|:::|.||.|.||..::||:|..||.:||.||...|||.|.|||:||
Zfish   120 LLIIEPTSQAVIAITFANYLVQPLFPTCEPPYSASRLIAAACICLLTFINSAYVKWGTRVQDVFT 184

  Fly   201 YAKLLALFIIIATGVYQLYLGNTQYF--TFENTDTKVTSIALSFYSGLFAYNGWNYLNFIIEELK 263
            |||:|||.:||.||:.:|..|.|..|  :|:.:......|||:.||.||:|:||:.|||:.||:|
Zfish   185 YAKVLALIVIIITGIVKLCQGFTINFEDSFQGSSRDPGGIALALYSALFSYSGWDTLNFVTEEIK 249

  Fly   264 DPVKNLPRAIAISCTLVTIVYVMANVSFYTILSPDEVMGSSAVAVTYAERAFGMLAWTIPVFVAL 328
            :|.:|||.:||||..:|||:|::.||::|.:|....::.|.|||||:|:...|:::||||:.|||
Zfish   250 NPERNLPLSIAISMPIVTIIYILTNVAYYAVLDMSAILASDAVAVTFADHTLGVMSWTIPIAVAL 314

  Fly   329 STFGAVNGILLTSSRLFYAGANNGQMPEILTMIQIQRFTPTPAVLAMALLSMLYLTVSDIFALIN 393
            |.:|.:|..::.:||||:.||..|.:|:.|:||.|:||||.||:|....::::||||.|:|.|||
Zfish   315 SCYGGLNSSIIAASRLFFVGAREGHLPDALSMIHIERFTPVPALLFNCAMALIYLTVEDVFQLIN 379

  Fly   394 YVGFATWLSIGVAVLCLPWLRWAQPNLPRPIRVPMVFPIVYLIATIFVTVVPMYASPVETGYGIL 458
            |..|:.|..:|:::....:|||.:|:.|||:::.:|:||::.:..:|:..||:|:..:.:..||.
Zfish   380 YYSFSYWFFVGLSIAGQIYLRWKEPDRPRPLKLSLVYPIIFCLCVVFLVAVPLYSDTLNSLIGIA 444

  Fly   459 MILSSIPVYL--VFIAWKNKPIWFQKTMVSLTRFLQ 492
            :.||.:|||.  :.:....:|....|.:.::|||.|
Zfish   445 IALSGVPVYFLGIHLPESKRPPIITKLLSAITRFTQ 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1607	NP_001263139.1	2A0308	42..501	CDD:273332	218/455 (48%)
slc7a6	XP_005166451.1	2A0308	2..489	CDD:273332	224/490 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593043
Domainoid	1	1.000	451	1.000	Domainoid score	I490
eggNOG	1	0.900	-	-		E2759_KOG1287
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H62496
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	1	1.010	-	-		D339093at33208
OrthoFinder	1	1.000	-	-		FOG0000064
OrthoInspector	1	1.000	-	-		otm25011
orthoMCL	1	0.900	-	-		OOG6_100314
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	1	1.000	-	-		X75
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.690