DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG1607 and SLC7A14

DIOPT Version :9

Sequence 1:	NP_001263139.1	Gene:	CG1607 / 43707	FlyBaseID:	FBgn0039844	Length:	507	Species:	Drosophila melanogaster
Sequence 2:	NP_066000.2	Gene:	SLC7A14 / 57709	HGNCID:	29326	Length:	771	Species:	Homo sapiens

Alignment Length:	448	Identity:	102/448 - (22%)
Similarity:	186/448 - (41%)	Gaps:	93/448 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 SIVNGNGDASAKLTNGDGDGGGDGGGEVTLKAKMSLLNGCTVIVGSIIGSGIFVSPTGVLMYTGS 80
            |::.|.|..:|..|.              |...::.::..::.|||.:|:|::| .:|::....:
Human    34 SMLEGTGTTTAHGTK--------------LAQVLTTVDLISLGVGSCVGTGMYV-VSGLVAKEMA 83

  Fly    81 VNLALIVWVISGLFSMVGAYCYAELGTMITK-SGADYAYIMETFGPFMAFIRLW---IECMIVRP 141
            ....::.::|:.:.|::...||||.|..:.| :|:.|.|...|.|.|:||...|   :|.:|...
Human    84 GPGVIVSFIIAAVASILSGVCYAEFGVRVPKTTGSAYTYSYVTVGEFVAFFIGWNLILEYLIGTA 148

  Fly   142 CSQAIVALTF---STYVLKPFFPECT--------PPEDSARLLAVCCILVLTLINCWDVKWATAV 195
            ...:.::..|   :.:.:..:..:..        ..|....|||:...:::|:|....||.:...
Human   149 AGASALSSMFDSLANHTISRWMADSVGTLNGLGKGEESYPDLLALLIAVIVTIIVALGVKNSIGF 213

  Fly   196 QDIFTYAKLLA-LFIIIATGVYQLYLGNTQYFTFENTDTKVTSIALSFYSGLFAYNGWN------ 253
            .::.....|.. :||:||    .|:..|.:|:.                .|.|..:||:
Human   214 NNVLNVLNLAVWVFIMIA----GLFFINGKYWA----------------EGQFLPHGWSGVLQGA 258

  Fly   254 ------YLNFII-----EELKDPVKNLPRAIAISCTLVTIVYVMAN------VSFYTILSPDEVM 301
                  ::.|.|     ||.|:|..::|.||..|..:....||..:      |.:|||.:...:|
Human   259 ATCFYAFIGFDIIATTGEEAKNPNTSIPYAITASLVICLTAYVSVSVILTLMVPYYTIDTESPLM 323

  Fly   302 GSSAVAVTYAER---AFGMLAWTIPVFVALSTFGAVNGILLTSSRLFYAGANNGQMPEILTMIQI 363
            ........||.:   |.|.:|.     :.:|..|:    |....|:.||.|.:|.:...|.  .:
Human   324 EMFVAHGFYAAKFVVAIGSVAG-----LTVSLLGS----LFPMPRVIYAMAGDGLLFRFLA--HV 377

  Fly   364 QRFTPTPAVLAMA---LLSMLYLTVSDIFALINYVGFATWLSIGVAVLCLPWLRWAQP 418
            ..:|.||.|..:.   |.::|.|.|| :..||..:...|.|:..:..:|:..||: ||
Human   378 SSYTETPVVACIVSGFLAALLALLVS-LRDLIEMMSIGTLLAYTLVSVCVLLLRY-QP 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG1607	NP_001263139.1	2A0308	42..501	CDD:273332	97/422 (23%)
SLC7A14	NP_066000.2	2A0303	48..677	CDD:273330	97/434 (22%)
		AA_permease_C	627..677	CDD:290617
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	736..771
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53617
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2200
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.950