Protein Alignment pHCl-2 and GLRA3

DIOPT Version :9

• Sequence 1: NP_001303470.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_006520.2
• Gene: GLRA3 / 8001
• HGNCID: 4328
• Length: 464
• Species: Homo sapiens
• Alignment Length: 500
• Identity: 139/500 - (27%)
• Similarity: 221/500 - (44%)
• Gaps: 88/500 - (17%)

  Fly    37 VVSPLNTTDAFSVSINLSQSTVNNCPSLKNAESMALMELLTRLTAPCRYDRMVPPVVHNKDGEEV 101
            :|:...|..|.|.|..:|.|..             |.:|:.|.:.   ||..:.|   |..|.
Human    25 LVATKETDSARSRSAPMSPSDF-------------LDKLMGRTSG---YDARIRP---NFKGP-- 68

  Fly   102 PMDIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRR---QPIMGESELKKMLW 163
            |:::....:|....::..:.:.:.|...|:.::.|||||:|.| |:..   .|.|.:|     :|
Human    69 PVNVTCNIFINSFGSIAETTMDYRVNIFLRQKWNDPRLAYSEY-PDDSLDLDPSMLDS-----IW 127

  Fly   164 VPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESW 228
            .|.:|..||:.:.....:..::|..|:.||.||.|.||..||.|.|:.:.||.|.|.|...|||:
Human   128 KPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESF 192

  Fly   229 MYNTTLVQLHWETDNPVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLL 293
            .|....:...|:.:.||...:.|.|.::.|   ...:.:|...:.|.:     |.::.|.....|
Human   193 GYTMNDLIFEWQDEAPVQVAEGLTLPQFLL---KEEKDLRYCTKHYNT-----GKFTCIEVRFHL 249

  Fly   294 TREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVT 358
            .|::|||:|..::||::||.:||||||:..|..|||..||.||:|:..|.|.....:|.|||||.
Human   250 ERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVK 314

  Fly   359 MSEVWFLVCTIFIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRRHGYRRTDS 423
            ..::|..||.:|:|.:|:|:|.||.:.|::.:|...:|..|   ..|....|:|..|......:.
Human   315 AIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRK---NKTEAFALEKFYRFSDMDDEV 376

  Fly   424 TMSTMSTTSMDK-TC----------GPNNTVITIETPIIIGGSLSREDSAISLDEQDETSTSESS 477
            ..|..|.|:... .|          |||:.|                               :..
Human   377 RESRFSFTAYGMGPCLQAKDGMTPKGPNHPV-------------------------------QVM 410

  Fly   478 DSSKEKPAQTFATMTPKEVSLWIDRKMRFVFPLSFIVFNALFWTL 522
            ..|.::..:.|.....|     ||...|..|||:|::||..:|.:
Human   411 PKSPDEMRKVFIDRAKK-----IDTISRACFPLAFLIFNIFYWVI 450

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	137/489 (28%)
GLRA3	NP_006520.2	LIC	12..451	CDD:273305	139/499 (28%)
		Strychnine-binding. /evidence=ECO:0000269|PubMed:26416729	235..240		2/9 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910