Protein Alignment pHCl-2 and gabrg2

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: XP_031754595.1
• Gene: gabrg2 / 779514
• XenbaseID: XB-GENE-5949005
• Length: 505
• Species: Xenopus tropicalis
• Alignment Length: 448
• Identity: 111/448 - (24%)
• Similarity: 190/448 - (42%)
• Gaps: 67/448 - (14%)

  Fly    85 YDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRR 149
            ||..:.|.:..|     |..|:...|:..:..:::.::::|:.......:.|.||.|:|.:...|
 Frog   107 YDNKLRPDIGVK-----PTVIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIKVLR 166

  Fly   150 QPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKF 214
            .    .|.:...:|:|..|..|.:.:.....:..:.:..|:.:|.||.:.||.....|.:....|
 Frog   167 L----NSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQLQLHNF 227

  Fly   215 PFDEQKCKTTLESWMYNTTLVQLHWETDN-PVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHG 278
            |.||..|.....|:.|....:...|:..: .|...:..:|.:::.:| |.|.:..|...|
 Frog   228 PMDEHSCPLEFSSYGYPKEEIIYQWKRSSVEVGDVRSWRLYQFSFVG-LRNTTEEVKTTS----- 286

  Fly   279 SLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITL 343
               |:|.:::....|:|.:||:.|..::|..:||.:||||||:..|..||||:||.||:|:..||
 Frog   287 ---GDYVVMTVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITTVLTMTTL 348

  Fly   344 SLSQENNLMKVSYVTMSEVWFLVCTIFIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVP 408
            |.....:|.||||||..:::..||.||:|.:|:|:.                 |..|     ||.
 Frog   349 STIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYG-----------------TLHY-----FVS 391

  Fly   409 HLKKHRRHGYRRTDSTMSTMSTTSMDKTCGPNNTVITIETPIIIGGSLSREDSAISLDEQDETST 473
            :.|..:....::.:..:...|..:......|.:..|.:             ::|..|.|:||...
 Frog   392 NRKPSKDKEKKKKNPLLWMFSFKAPTIDIRPRSATIQM-------------NNATHLQERDEEYG 443

  Fly   474 SESSDSSKEKPAQTFATMTPKEVSLW-----------IDRKMRFVFPLSFIVFNALFW 520
            .|..|.  :..|..|..........|           ||...|..||.:|.:||.::|
 Frog   444 YECLDG--KDCASFFCCFEDCRTGAWRHGRIHIRVAKIDSYSRIFFPTAFCLFNLVYW 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	111/448 (25%)
gabrg2	XP_031754595.1	LIC	99..502	CDD:455710	111/448 (25%)
		LGIC_ECD_GABAAR_G	120..301	CDD:349801	39/193 (20%)
		Cys-loop	220..234	CDD:349801	5/13 (38%)