DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pHCl-2 and Gabrq

DIOPT Version :9

Sequence 1:	NP_001303470.1	Gene:	pHCl-2 / 43703	FlyBaseID:	FBgn0039840	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_065234.1	Gene:	Gabrq / 57249	MGIID:	1888498	Length:	638	Species:	Mus musculus

Alignment Length:	628	Identity:	144/628 - (22%)
Similarity:	242/628 - (38%)	Gaps:	190/628 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    53 LSQST------VNNCPSLKNAESMALME-LLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFY 110
            ||.||      :.||   ||..:.|::: :|.|:.:  .||..:.|   |..|..||:.:  ..|
Mouse    36 LSSSTPEVILDLFNC---KNCANEAVVQKILDRVLS--TYDVRLRP---NFGGAPVPVSV--SIY 90

  Fly   111 IYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTNEQAS 175
            :..::.:...::.:|:...|...:.|.|||:  |..|....:  :..:.:.||||..:..|.:.:
Mouse    91 VSSIEQISEINMDYTITMFLHQTWKDTRLAY--YETNLNLTL--DYRMHEKLWVPDCYFVNSKDA 151

  Fly   176 TVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHWE 240
            .|...:.::.:..::|:|||....||..|..|.::.||||.|:|.||..:||:.|....:.|.||
Mouse   152 FVHDVTVENRVFQLHPDGTVRYGIRLTTTAACSLDLQKFPMDKQSCKLEVESYGYTVEDIVLSWE 216

  Fly   241 TDNPVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYS--IISFTVLLTREVGYYVID 303
            .||.:.....|.:.:|..:|...     .|.|.|...||    |.  |:.|.|  .|||..|::.
Mouse   217 DDNAIHITDGLHIPQYTYLGRTI-----TSKEVYFYTGS----YMRLIVKFQV--QREVRSYLVQ 270

  Fly   304 YFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFLVCT 368
            .:.|:::...:||:|||:..|.:.||.|:|.|::|...|:.....:.|..:|.:...:::.|||.
Mouse   271 VYWPTVLTTILSWISFWMNYDSSAARVTIGLTSILVLTTIDSHMRDKLPHISCIKAIDIYILVCL 335

  Fly   369 IFIFGSLVEFAFVNTIW-----RRNNDLQLKKR--TTKY-------------------------- 400
            .|:|.||:|:.::|.::     |||:....|.|  ..:|
Mouse   336 FFVFLSLLEYVYINYLFFSQVPRRNHRRCRKPRRVVARYRYQEVVVANVQDGLINVEDRVEDRAG 400

  Fly   401 -IVKSTFVPHLKKHRRHG---YRRTDSTMSTMSTTSMDKTCGPNNTVITIET------------- 448
             :..|....||......|   :....:.::|..:.|:..:......:.|.|:
Mouse   401 PLPDSPMQAHLASQESLGSLVFTSEQAQLATSESLSLLSSASSQTQLATGESLSDLPSTSEQTVP 465

  Fly   449 ----------------PIIIGG------------SLSREDSA----------------------- 462
                            ||.|..            |||.|:|.
Mouse   466 ECTIHFHGFLTNDSIIPIKIHSRSDACDDEDSEESLSSEESHGHGSSHTGRLKLQISQRCVQEAS 530

  Fly   463 -------------------ISLDE---------------------QDETSTSESSDSSKEKPAQT 487
                               :.|||                     |::.|:|||.::....|..:
Mouse   531 WDLDKIEILQDDISITSSWLGLDEQCKGDADSIWSLTDEELMACDQEKDSSSESEENCSPSPGCS 595

  Fly   488 F----------ATMTPKEVSLWIDRKMRFVFPLSFIVFNALFW 520
            |          ....||     :||..||:|||||.:||.::|
Mouse   596 FNEGFSFQLFKPNRVPK-----VDRWSRFLFPLSFGLFNVVYW 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	144/628 (23%)
Gabrq	NP_065234.1	LGIC_ECD_GABAAR_theta	82..263	CDD:349804	53/197 (27%)
		Cys-loop	183..197	CDD:349804	7/13 (54%)
		LGIC_TM_GABAAR_theta	266..365	CDD:349858	29/98 (30%)
		TM1 helix	266..289	CDD:349858	7/22 (32%)
		TM2 helix	293..317	CDD:349858	7/23 (30%)
		TM3 helix	325..351	CDD:349858	9/25 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	491..515		5/23 (22%)
		LGIC_TM	<604..636	CDD:365787	14/35 (40%)
		TM4 helix	612..633	CDD:349850	12/25 (48%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810