DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pHCl-2 and gabrg1

DIOPT Version :9

Sequence 1:	NP_001303470.1	Gene:	pHCl-2 / 43703	FlyBaseID:	FBgn0039840	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	XP_009305483.1	Gene:	gabrg1 / 556202	ZFINID:	ZDB-GENE-141215-66	Length:	454	Species:	Danio rerio

Alignment Length:	530	Identity:	128/530 - (24%)
Similarity:	217/530 - (40%)	Gaps:	108/530 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 IFVLISYLGLSSAAGVHLGDLQ--QNLAANGSVVVSPLNTTDAFSVSINLSQSTVNNCPSLKNAE 68
            :::|...||:..|.|....:.:  :::..|.:.|:||           .:.:|.|
Zfish    12 VWLLPGLLGVCMAFGPSKAEEEDYEDVPINKTWVLSP-----------KVYESDV---------- 55

  Fly    69 SMALMELLTRLTAPCRYDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLDSSDLQFTVQGLLQLR 133
            ::.|.:||.......|.|..|.|.|           |....|:..:..:|..::::|:.......
Zfish    56 TLILNKLLQGYDNKLRPDIGVRPTV-----------IETAVYVNSIGPVDPINMEYTIDIFFAQT 109

  Fly   134 YLDPRLAFSSYLPNRRQPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTS 198
            :.|.||.|:|.:    :.:|..|.:...:|:|..|..|.:.|.....:..:.|..::.||.|:.:
Zfish   110 WYDSRLKFNSSM----KLLMLNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRLWSNGRVMYT 170

  Fly   199 TRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHWETDN-PVSFDKQLQLTEYNLIGSL 262
            .||.....|::....||.||..|.....|:.|....:|..|:..: .|:..:..:|.::..:| |
Zfish   171 LRLTINAECYLKLHNFPMDEHSCPLEFSSYGYPKNEIQYRWQRRSVEVADQRYWRLYQFAFVG-L 234

  Fly   263 YNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTP 327
            .|.|...:.:|        |.|.:::....|:|.:||:.|..::|..|||.:||||||:..|..|
Zfish   235 RNSSDVANTQS--------GEYVVMTIFFDLSRRMGYFTIQTYIPCSMIVVLSWVSFWINKDAVP 291

  Fly   328 ARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFLVCTIFIFGSLVEFAFVNTIWRRNNDLQ 392
            |||:||.||:|:..|||.....:|.||||||..:::..||.||.|.:|:|:   .|:....::.|
Zfish   292 ARTSLGITTVLTMTTLSTISRKSLPKVSYVTAMDLFVSVCFIFTFAALMEY---GTLHYFTSNRQ 353

  Fly   393 LKKRTTKYIVKSTFVPHLKKHRRHGYRRTDSTMSTMSTTSMDKTCGPNNTVITIETPIIIGGSLS 457
            .||..:.:..|.:.|                            ...|..:::.:..   |.....
Zfish   354 NKKTKSSHAQKPSMV----------------------------NIRPGTSLLQMNN---IAPYHE 387

  Fly   458 REDSAIS-LDEQDETSTSESSDSSKEKPAQTFATMTPKEVSLW-----------IDRKMRFVFPL 510
            .:|.|.. ||.:|.||              .|..........|           ||...|..||.
Zfish   388 DDDYAYECLDGKDCTS--------------FFCCFDDCRSGAWRENRMHVHVSKIDSYSRIFFPT 438

  Fly   511 SFIVFNALFW 520
            :|.:||.::|
Zfish   439 AFGLFNLVYW 448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	119/488 (24%)
gabrg1	XP_009305483.1	Neur_chan_LBD	56..261	CDD:280998	51/228 (22%)
		LIC	58..451	CDD:273305	117/463 (25%)
		Neur_chan_memb	268..448	CDD:280999	62/227 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.000