DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment pHCl-2 and nAChRbeta2

DIOPT Version :9

Sequence 1:	NP_001303470.1	Gene:	pHCl-2 / 43703	FlyBaseID:	FBgn0039840	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_524483.1	Gene:	nAChRbeta2 / 42920	FlyBaseID:	FBgn0004118	Length:	519	Species:	Drosophila melanogaster

Alignment Length:	511	Identity:	117/511 - (22%)
Similarity:	187/511 - (36%)	Gaps:	151/511 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 YDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAFSS------ 143
            |:|::.|||:|.:...|.:.:.....|.|  ||.:..:  |....::.|:.|.:|.:..
  Fly    41 YNRLIRPVVNNTETLTVWLGLKLSQLIEV--NLKNQVM--TTNLWVKQRWFDYKLRWDPEEYGGV 101

  Fly   144 ---YLPNRRQPIMGESELKKMLWVPHIFLTNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQAT- 204
               |:|:..            :|||.|.|.|......              ..|::|...|:.|
  Fly   102 EQLYVPSEH------------IWVPDIVLYNNWDGNY--------------EVTLMTKATLKYTG 140

  Fly   205 --------LY---CWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHWETDNPVSFDKQ--LQLTEY 256
                    :|   |.||.:.||:|||.|.....||.||...|.|......|.|...|  :.|||:
  Fly   141 EVFWEPPAIYKSSCEMNVEYFPYDEQICFMKFGSWTYNGAQVDLKHLDQIPGSNLVQVGIDLTEF 205

  Fly   257 NLIGSLYNESIRV---SNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVS 318
            .|  |:..:.:.|   .||.|.. .:|| .:|.|:|.:.:.|:..:|.::..:|.:.:..::.:.
  Fly   206 YL--SVEWDILEVPATKNEEYYP-DTLE-PFSDITFKLTMRRKTLFYTVNLIVPCVALTFLTVLV 266

  Fly   319 FWLQADQTPARTTLGCTTLLSFIT----------------LSLSQENNLMKVSYVTMSEVWFLVC 367
            |:|.:| :..:.|| |.::|..:|                :.|..:..|..:..|::| ||..||
  Fly   267 FYLPSD-SGEKVTL-CISILVSLTVFFLLLAEIIPPTSLAVPLLGKYLLFTMILVSLS-VWTTVC 328

  Fly   368 TIFIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRRHGYR---RTDSTMSTMS 429
            .:            |..:|..:...:.....|..:.  |:|.|...||..|.   ..|||.|...
  Fly   329 VL------------NIHFRSPSTHNMSPLVRKLFLH--FMPKLMMMRRTQYTLPDYDDSTPSNGY 379

  Fly   430 TTSMDKTCGPNNTVITIETPIIIGGSLSREDSAISLDEQD---ETSTSESSDSSKEKPAQTFATM 491
            |..:|                 :..|:|...|... |.||   :.....|.||....|    ..:
  Fly   380 TNEID-----------------VRDSISDFPSEFK-DSQDGAYDNGMQNSVDSDNVIP----RNL 422

  Fly   492 TP-----------------------------KEVSLWIDRKMRFVFPLSFIVFNAL 518
            ||                             |.||:.:||...::|.|| .||..|
  Fly   423 TPEVLQALRAVRFIAQHIKDADKDNEIVEDWKFVSMVLDRFFLWLFTLS-CVFGTL 477

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	117/511 (23%)
nAChRbeta2	NP_524483.1	LIC	9..479	CDD:273305	117/511 (23%)
nAChRbeta2	NP_524483.1	LGIC_ECD_nAChR_proto_alpha-like	29..247	CDD:349832	61/239 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447276
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030