Protein Alignment pHCl-2 and nAChRalpha2

DIOPT Version :10

• Sequence 1: NP_651861.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_524482.1
• Gene: nAChRalpha2 / 42919
• FlyBaseID: FBgn0000039
• Length: 576
• Species: Drosophila melanogaster
• Alignment Length: 352
• Identity: 77/352 - (21%)
• Similarity: 145/352 - (41%)
• Gaps: 59/352 - (16%)

  Fly    85 YDRMVPPVVHNKDGEEVPMDIYARFYIYVMKNLDSSDLQFTVQGLLQLRYLDPRLAF--SSYLPN 147
            |:|::.||.:|.|...|.:.:.....|    :|:..|...|....|:..:.|.:..:  |.|
  Fly    56 YNRLIRPVSNNTDTVLVKLGLRLSQLI----DLNLKDQILTTNVWLEHEWQDHKFKWDPSEY--- 113

  Fly   148 RRQPIMGESEL---KKMLWVPHIFL-TNEQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLYCW 208
                 .|.:||   .:.:|:|.|.| .|.....|:.|..|   ..::..|.|:.:........|.
  Fly   114 -----GGVTELYVPSEHIWLPDIVLYNNADGEYVVTTMTK---AILHYTGKVVWTPPAIFKSSCE 170

  Fly   209 MNFQKFPFDEQKCKTTLESWMYNTTLVQLHW-----ETDNPVSFDKQLQ----LTEYNLIGSLYN 264
            ::.:.||||:|.|.....||.|:...:.|..     :.||.|.....|:    ..|::::|....
  Fly   171 IDVRYFPFDQQTCFMKFGSWTYDGDQIDLKHISQKNDKDNKVEIGIDLREYYPSVEWDILGVPAE 235

  Fly   265 ESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPAR 329
            .     :|.|  :......|..|.|.:.|.|:..:|.::..:|.:.|..:|.:.|:|.|| :..:
  Fly   236 R-----HEKY--YPCCAEPYPDIFFNITLRRKTLFYTVNLIIPCVGISYLSVLVFYLPAD-SGEK 292

  Fly   330 TTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVW-------FLVCTIFIFG--SLVEFAFVNTIW 385
            ..| |.::|      |||....:.:|.:..|...       :|:.|:.:.|  .::....:|..:
  Fly   293 IAL-CISIL------LSQTMFFLLISEIIPSTSLALPLLGKYLLFTMLLVGLSVVITIIILNIHY 350

  Fly   386 RRNNDLQLKKRTTKYIVKSTFVPHLKK 412
            |:.:..:::.     .::|.|:..|.|
  Fly   351 RKPSTHKMRP-----WIRSFFIKRLPK 372

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_651861.1	LIC	46..522	CDD:455710	77/352 (22%)
nAChRalpha2	NP_524482.1	LGIC_ECD_nAChR_proto_alpha-like	44..263	CDD:349832	52/228 (23%)
		LIC	47..544	CDD:455710	77/352 (22%)
		Cys-loop	169..183	CDD:349832	6/13 (46%)