Protein Alignment pHCl-2 and nAChRbeta1

DIOPT Version :9

• Sequence 1: NP_001303470.1
• Gene: pHCl-2 / 43703
• FlyBaseID: FBgn0039840
• Length: 526
• Species: Drosophila melanogaster
• Sequence 2: NP_523927.2
• Gene: nAChRbeta1 / 38545
• FlyBaseID: FBgn0000038
• Length: 521
• Species: Drosophila melanogaster
• Alignment Length: 441
• Identity: 100/441 - (22%)
• Similarity: 147/441 - (33%)
• Gaps: 141/441 - (31%)

  Fly   162 LWVPHIFLTN--------EQASTVLGTSAKDELTSIYPNGTVLTSTRLQATLY---CWMNFQKFP 215
            :|.|.|.|.|        ...|.||          |||.|.||.   :...:|   |.::...||
  Fly   109 VWKPDIVLFNNADGNYEVRYKSNVL----------IYPTGEVLW---VPPAIYQSSCTIDVTYFP 160

  Fly   216 FDEQKCKTTLESWMYNTTLVQLHWETDNPVSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGS- 279
            ||:|.|.....||.:|...|.|                       :|||....|....|...|:
  Fly   161 FDQQTCIMKFGSWTFNGDQVSL-----------------------ALYNNKNFVDLSDYWKSGTW 202

  Fly   280 -----------LEGN-----YSIISFTVLLTREVGYYVIDYFLPSIMIVTISWVSFWLQADQTPA 328
                       .||:     .:.|:|.:::.|:..:|.::..||:::|..:..:.|:|.| :...
  Fly   203 DIIEVPAYLNVYEGDSNHPTETDITFYIIIRRKTLFYTVNLILPTVLISFLCVLVFYLPA-EAGE 266

  Fly   329 RTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFLVCTIFIFGS---LVEFAFVNTIWR--RN 388
            :.|||.:.|||.:...|.....|...|.|......:|:.| ||..:   ||....:|..:|  |.
  Fly   267 KVTLGISILLSLVVFLLLVSKILPPTSLVLPLIAKYLLFT-FIMNTVSILVTVIIINWNFRGPRT 330

  Fly   389 NDLQLKKRT--TKYIVKSTFV----------------------PH--------LKKHRRHGYRRT 421
            :.:.:..|:  ..|:....|:                      ||        |.||    ....
  Fly   331 HRMPMYIRSIFLHYLPAFLFMKRPRKTRLRWMMEMPGMSMPAHPHPSYGSPAELPKH----ISAI 391

  Fly   422 DSTMSTMSTTSMDKTCGPNNTVITIETPIIIGGSLSREDSAISLDEQDETSTSESSDSSKEKPAQ 486
            ....|.|....:.....||   ..|...:..||.|...|..        ...||||||....|..
  Fly   392 GGKQSKMEVMELSDLHHPN---CKINRKVNSGGELGLGDGC--------RRESESSDSILLSPEA 445

  Fly   487 TFATMTP--------------------KEVSLWIDRKMRFVFPLSFIVFNA 517
            :.||...                    |.|::.|||...::|   |||..|
  Fly   446 SKATEAVEFIAEHLRNEDLYIQTREDWKYVAMVIDRLQLYIF---FIVTTA 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	100/441 (23%)
nAChRbeta1	NP_523927.2	LIC	8..500	CDD:273305	100/441 (23%)
		Neur_chan_LBD	28..236	CDD:280998	38/162 (23%)
		Neur_chan_memb	243..498	CDD:280999	61/271 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45447282
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR18945
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030