DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pHCl-2 and Glra4

DIOPT Version :9

Sequence 1:	NP_001303470.1	Gene:	pHCl-2 / 43703	FlyBaseID:	FBgn0039840	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001178843.1	Gene:	Glra4 / 367912	RGDID:	1564103	Length:	456	Species:	Rattus norvegicus

Alignment Length:	495	Identity:	136/495 - (27%)
Similarity:	218/495 - (44%)	Gaps:	91/495 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 VSINLSQSTVNNCPSLKNAESMALMELLTRLTA-PCRYDRMVPPVVHNKDGEEVPMDIYARFYIY 112
            :|:.|::..|.:.|  |.::.|:..:.|.:|.. ...||..:.|   |..|.  |:::....:|.
  Rat    22 LSVALAKEDVKSGP--KGSQPMSPSDFLDKLMGRTSGYDARIRP---NFKGP--PVNVTCNIFIN 79

  Fly   113 VMKNLDSSDLQFTVQGLLQLRYLDPRLAFSSYLPNRR---QPIMGESELKKMLWVPHIFLTNEQA 174
            ...::..:.:.:.|...|:.::.|||||:..| |:..   .|.|.:|     :|.|.:|..||:.
  Rat    80 SFGSVTETTMDYRVNVFLRQQWNDPRLAYREY-PDDSLDLDPSMLDS-----IWKPDLFFANEKG 138

  Fly   175 STVLGTSAKDELTSIYPNGTVLTSTRLQATLYCWMNFQKFPFDEQKCKTTLESWMYNTTLVQLHW 239
            :.....:..::|..|:.||.||.|.||...|.|.|:.:.||.|.|.|...|||:.|....:...|
  Rat   139 ANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCPMDLKNFPMDIQTCTMQLESFGYTMNDLMFEW 203

  Fly   240 ETDNP-VSFDKQLQLTEYNLIGSLYNESIRVSNESYMSHGSLEGNYSIISFTVLLTREVGYYVID 303
            ..|.| |...:.|.|.::.|...        .:..|.:.....|.::.|.....|.|::|||:|.
  Rat   204 LEDAPAVQVAEGLTLPQFILRDE--------KDLGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQ 260

  Fly   304 YFLPSIMIVTISWVSFWLQADQTPARTTLGCTTLLSFITLSLSQENNLMKVSYVTMSEVWFLVCT 368
            .::||::||.:||||||:..|..|||..||.||:|:..|.|.....:|.|||||...::|..||.
  Rat   261 MYIPSLLIVILSWVSFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCL 325

  Fly   369 IFIFGSLVEFAFVNTIWRRNNDLQLKKRTTKYIVKSTFVPHLKKHRRH--------------GYR 419
            :|:|.:|:|:|.||.:.|::.:....:|              |:.|||              ||
  Rat   326 LFVFAALLEYAAVNFVSRQHKEFMRLRR--------------KQRRRHMEEDIIREGRFYFRGY- 375

  Fly   420 RTDSTMSTMSTTSMDKTCGPNNTVITIETPIIIGGSLSREDSAISLDEQDETSTSESSDSSKEKP 484
                   .:......:..||           :.|.|:.......:|.::.||......|.:|.
  Rat   376 -------GLGHCLQARDGGP-----------MEGSSIYSPQPPTTLLKEGETMRKVYVDRAKR-- 420

  Fly   485 AQTFATMTPKEVSLWIDRKMRFVFPLSFIVFNALFWTLVY 524
                           ||...|.|||.:|:|||..:| :||
  Rat   421 ---------------IDTISRAVFPFTFLVFNIFYW-VVY 444

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pHCl-2	NP_001303470.1	LIC	46..522	CDD:273305	134/491 (27%)
Glra4	NP_001178843.1	LIC	9..444	CDD:273305	134/493 (27%)
		Neur_chan_LBD	47..254	CDD:280998	59/225 (26%)
		Neur_chan_memb	261..441	CDD:280999	64/229 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3644
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR18945
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910